Publications

All our publications

*Listed are the articles found in the PubMed database.

Publications by “Juan Manuel Zapata Hernández”

CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects.

Glez-Vaz, J, Azpilikueta, A, Ochoa, MC, Olivera, I, Gomis, G, Cirella, A, Luri-Rey, C, Álvarez, M, Pérez-Gracia, JL, Ciordia, S, Eguren-Santamaria, I, Alexandru, R, Berraondo, P, de Andrea, C, Teijeira, Á, Corrales, F, Zapata, JM , Melero, I.

JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia.

Aranda-Tavío, H, Recio, C, Martín-Acosta, P, Guerra-Rodríguez, M, Brito-Casillas, Y, Blanco, R, Junco, V, León, J, Montero, JC, Gandullo-Sánchez, L, McNaughton-Smith, G, Zapata, JM , Pandiella, A, Amesty, A, Estévez-Braun, A, Fernández-Pérez, L, Guerra, B.

Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR.

Compte, M, Harwood, SL, Martínez-Torrecuadrada, J, Perez-Chacon, G , González-García, P, Tapia-Galisteo, A, Van Bergen En Henegouwen, PMP, Sánchez, A, Fabregat, I, Sanz, L, Zapata, JM , Alvarez-Vallina, L.

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.

Compte, M, Harwood, SL, Muñoz, IG, Navarro, R, Zonca, M, Perez-Chacon, G , Erce-Llamazares, A, Merino, N, Tapia-Galisteo, A, Cuesta, AM, Mikkelsen, K, Caleiras, E, Nuñez-Prado, N, Aznar, MA, Lykkemark, S, Martínez-Torrecuadrada, J, Melero, I, Blanco, FJ, Bernardino de la Serna, J, Zapata, JM , Sanz, L, Alvarez-Vallina, L.

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB).

Azpilikueta, A, Bolaños, E, Lang, V, Labiano, S, Aznar, MA, Etxeberria, I, Teijeira, A, Rodriguez-Ruiz, ME, Perez-Gracia, JL, Jure-Kunkel, M, Zapata, JM , Rodriguez, MS, Melero, I.

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.

Santacatterina, F, Sánchez-Cenizo, L, Formentini, L, Mobasher, MA, Casas, E, Rueda, CB, Martínez-Reyes, I, Núñez de Arenas, C, García-Bermúdez, J, Zapata, JM , Sánchez-Aragó, M, Satrústegui, J, Valverde, ÁM , Cuezva, JM.

Anti-CCR7 therapy exerts a potent anti-tumor activity in a xenograft model of human mantle cell lymphoma.

Somovilla-Crespo, B, Alfonso-Pérez, M, Cuesta-Mateos, C, Carballo-de Dios, C, Beltrán, AE, Terrón, F, Pérez-Villar, JJ, Gamallo-Amat, C, Pérez-Chacón, G , Fernández-Ruiz, E, Zapata, JM , Muñoz-Calleja, C.

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Martinez-Forero, I, Azpilikueta, A, Bolaños-Mateo, E, Nistal-Villan, E, Palazon, A, Teijeira, A, Perez-Chacon, G , Morales-Kastresana, A, Murillo, O, Jure-Kunkel, M, Zapata, JM , Melero, I.

Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia.

Cuesta-Mateos, C, López-Giral, S, Alfonso-Pérez, M, de Soria, VG, Loscertales, J, Guasch-Vidal, S, Beltrán, AE, Zapata, JM , Muñoz-Calleja, C.

Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.

Kress, CL, Konopleva, M, Martínez-García, V, Krajewska, M, Lefebvre, S, Hyer, ML, McQueen, T, Andreeff, M, Reed, JC, Zapata, JM .

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.

Fukushima, T, Matsuzawa, S, Kress, CL, Bruey, JM, Krajewska, M, Lefebvre, S, Zapata, JM , Ronai, Z, Reed, JC.

Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury.

Bailly-Maitre, B, Fondevila, C, Kaldas, F, Droin, N, Luciano, F, Ricci, JE, Croxton, R, Krajewska, M, Zapata, JM , Kupiec-Weglinski, JW, Farmer, D, Reed, JC.

Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint.

Fukushima, T, Zapata, JM , Singha, NC, Thomas, M, Kress, CL, Krajewska, M, Krajewski, S, Ronai, Z, Reed, JC, Matsuzawa, S.

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.

Samuel, T, Welsh, K, Lober, T, Togo, SH, Zapata, JM , Reed, JC.

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

Hyer, ML, Croxton, R, Krajewska, M, Krajewski, S, Kress, CL, Lu, M, Suh, N, Sporn, MB, Cryns, VL, Zapata, JM , Reed, JC.

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

Samuel, T, Okada, K, Hyer, M, Welsh, K, Zapata, JM , Reed, JC.

TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice.

Zapata, JM , Krajewska, M, Morse, HC, Choi, Y, Reed, JC.

Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival.

Lo, JF, Hayashi, M, Woo-Kim, S, Tian, B, Huang, JF, Fearns, C, Takayama, S, Zapata, JM , Yang, Y, Lee, JD.

BAG1 over-expression in brain protects against stroke.

Kermer, P, Digicaylioglu, MH, Kaul, M, Zapata, JM , Krajewska, M, Stenner-Liewen, F, Takayama, S, Krajewski, S, Lipton, SA, Reed, JC.

Comparative analysis of apoptosis and inflammation genes of mice and humans.

Reed, JC, Doctor, K, Rojas, A, Zapata, JM , Stehlik, C, Fiorentino, L, Damiano, J, Roth, W, Matsuzawa, S, Newman, R, Takayama, S, Marusawa, H, Xu, F, Salvesen, G, Godzik, A, , , , .

The bioenergetic signature of cancer: a marker of tumor progression.

Cuezva, JM, Krajewska, M, de Heredia, ML, Krajewski, S, Santamaría, G, Kim, H, Zapata, JM , Marusawa, H, Chamorro, M, Reed, JC.

The triterpenoid CDDO induces apoptosis in refractory CLL B cells.

Pedersen, IM, Kitada, S, Schimmer, A, Kim, Y, Zapata, JM , Charboneau, L, Rassenti, L, Andreeff, M, Bennett, F, Sporn, MB, Liotta, LD, Kipps, TJ, Reed, JC.

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

Pedersen, IM, Kitada, S, Leoni, LM, Zapata, JM , Karras, JG, Tsukada, N, Kipps, TJ, Choi, YS, Bennett, F, Reed, JC.

Expression of Bcl-2 family member Bid in normal and malignant tissues.

Krajewska, M, Zapata, JM , Meinhold-Heerlein, I, Hedayat, H, Monks, A, Bettendorf, H, Shabaik, A, Bubendorf, L, Kallioniemi, OP, Kim, H, Reifenberger, G, Reed, JC, Krajewski, S.

Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system.

Krajewska, M, Mai, JK, Zapata, JM , Ashwell, KW, Schendel, SL, Reed, JC, Krajewski, S.

Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.

Meinhold-Heerlein, I, Stenner-Liewen, F, Liewen, H, Kitada, S, Krajewska, M, Krajewski, S, Zapata, JM , Monks, A, Scudiero, DA, Bauknecht, T, Reed, JC.

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.

Zapata, JM , Krajewska, M, Krajewski, S, Kitada, S, Welsh, K, Monks, A, McCloskey, N, Gordon, J, Kipps, TJ, Gascoyne, RD, Shabaik, A, Reed, JC.

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

Kitada, S, Zapata, JM , Andreeff, M, Reed, JC.

The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.

Zapata, JM , Matsuzawa, S, Godzik, A, Leo, E, Wasserman, SA, Reed, JC.

CD40-mediated activation of Ig-Cgamma1- and Ig-cepsilon germ-line promoters involves multiple TRAF family proteins.

Leo, E, Zapata, JM , Reed, JC.

TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

Ye, X, Mehlen, P, Rabizadeh, S, VanArsdale, T, Zhang, H, Shin, H, Wang, JJ, Leo, E, Zapata, J , Hauser, CA, Reed, JC, Bredesen, DE.

Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia.

Kitada, S, Zapata, JM , Andreeff, M, Reed, JC.

Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.

Leo, E, Welsh, K, Matsuzawa, S, Zapata, JM , Kitada, S, Mitchell, RS, Ely, KR, Reed, JC.

Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers.

Gil, J, Yamamoto, H, Zapata, JM , Reed, JC, Perucho, M.

Prognostic significance of apoptosis regulators in breast cancer.

Krajewski, S, Krajewska, M, Turner, BC, Pratt, C, Howard, B, Zapata, JM , Frenkel, V, Robertson, S, Ionov, Y, Yamamoto, H, Perucho, M, Takayama, S, Reed, JC.

Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

Takayama, S, Krajewski, S, Krajewska, M, Kitada, S, Zapata, JM , Kochel, K, Knee, D, Scudiero, D, Tudor, G, Miller, GJ, Miyashita, T, Yamada, M, Reed, JC.

TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.

Krajewska, M, Krajewski, S, Zapata, JM , Van Arsdale, T, Gascoyne, RD, Berern, K, McFadden, D, Shabaik, A, Hugh, J, Reynolds, A, Clevenger, CV, Reed, JC.

Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

Kitada, S, Andersen, J, Akar, S, Zapata, JM , Takayama, S, Krajewski, S, Wang, HG, Zhang, X, Bullrich, F, Croce, CM, Rai, K, Hines, J, Reed, JC.

Granzyme release and caspase activation in activated human T-lymphocytes.

Zapata, JM , Takahashi, R, Salvesen, GS, Reed, JC.

Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.

Kitada, S, Krajewska, M, Zhang, X, Scudiero, D, Zapata, JM , Wang, HG, Shabaik, A, Tudor, G, Krajewski, S, Myers, TG, Johnson, GS, Sausville, EA, Reed, JC.

Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors.

Zapata, JM , Krajewska, M, Krajewski, S, Huang, RP, Takayama, S, Wang, HG, Adamson, E, Reed, JC.

Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family.

Krajewski, S, Zapata, JM , Krajewska, M, VanArsdale, T, Shabaik, A, Gascoyne, RD, Reed, JC.

Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes.

Krajewski, S, Gascoyne, RD, Zapata, JM , Krajewska, M, Kitada, S, Chhanabhai, M, Horsman, D, Berean, K, Piro, LD, Fugier-Vivier, I, Liu, YJ, Wang, HG, Reed, JC.

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

Krajewska, M, Wang, HG, Krajewski, S, Zapata, JM , Shabaik, A, Gascoyne, R, Reed, JC.

CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator.

Eliopoulos, AG, Dawson, CW, Mosialos, G, Floettmann, JE, Rowe, M, Armitage, RJ, Dawson, J, Zapata, JM , Kerr, DJ, Wakelam, MJ, Reed, JC, Kieff, E, Young, LS.

Expression and function of alpha 4/beta 7 integrin on human natural killer cells.

Pérez-Villar, JJ, Zapata, JM , Melero, I, Postigo, A, Sánchez-Madrid, E, López-Botet, M.

B-cell homotypic adhesion through exon-A restricted epitopes of CD45 involves LFA-1/ICAM-1, ICAM-3 interactions, and induces coclustering of CD45 and LFA-1.

Zapata, JM , Campanero, MR , Marazuela, M, Sánchez-Madrid, F, de Landázuri, MO.

Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.

Arroyo, AG, Campanero, MR , Sánchez-Mateos, P, Zapata, JM , Ursa, MA, del Pozo, MA, Sánchez-Madrid, F.

Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos.

Zapata, JM , Martínez, MA , Sierra, JM.

Translational regulation of the heat shock response.

Sierra, JM, Zapata, JM .

Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages.

Zapata, JM , Pulido, R, Acevedo, A, Sánchez-Madrid, F, de Landázuri, MO.

Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock.

Zapata, JM , Maroto, FG, Sierra, JM.
Ministerio de ciencia, innovación y universidades
Consejo Superior de Investigaciones Científicas
Universidad Autónoma de Madrid
FEDER
Plan de Recuperación, Transformación y Resiliencia
Vicepresidencia, Consejería de Educación y Universidades
Unión Europea Next Generation
worldwidecancerresearch
Agencia Estatal de Investigación
Unión Europea Fondo Social Europeo
Instituto de Salud Carlos iii
España Puede
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