4 Oct | 2025 NLRP3 inflammasome and hearing loss: from mechanisms to therapies. Murillo-Cuesta, S , Seoane, E, Cervantes, B , Zubeldia, JM, Varela-Nieto, I . J Neuroinflammation - 22 (1) : 225 (PMID: 41046290) (doi:10.1186/s12974-025-03561-w)
12 Sep | 2025 Quinolylnitrone 23 Protects from Auditory Cell Oxidative Injury and Noise-Induced Hearing Loss. Murillo-Cuesta, S , Contreras, J , Chioua, M, García-Montoya, C, Rodríguez-de la Rosa, L , Méndez-Grande, I, Piotrowska, DG, Głowacka, IE, Varela-Nieto, I , Marco-Contelles, J. ACS Pharmacol Transl Sci - 8 (9) : 3007-3018 (PMID: 40969893) (doi:10.1021/acsptsci.5c00221)
15 Jan | 2025 A rare haplotype of the GJD3 gene segregating in familial Meniere's disease interferes with connexin assembly. Escalera-Balsera, A, Robles-Bolivar, P, Parra-Perez, AM, Murillo-Cuesta, S , Chua, HC, Rodríguez-de la Rosa, L , Contreras, J , Domarecka, E, Amor-Dorado, JC, Soto-Varela, A, Varela-Nieto, I , Szczepek, AJ, Gallego-Martinez, A, Lopez-Escamez, JA. Genome Med - 17 (1) : 4 (PMID: 39815343) (doi:10.1186/s13073-024-01425-1)
21 Apr | 2024 Tumors of the nervous system and hearing loss: Beyond vestibular schwannomas. Ruiz-García, C , Lassaletta, L , López-Larrubia, P , Varela-Nieto, I , Murillo-Cuesta, S . Hear Res - 447 : 109012 (PMID: 38703433) (doi:10.1016/j.heares.2024.109012)
11 Apr | 2024 A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study. Domínguez-Ruiz, M, Murillo-Cuesta, S , Contreras, J , Cantero, M, Garrido, G, Martín-Bernardo, B, Gómez-Rosas, E, Fernández, A, Del Castillo, FJ, Montoliu, L, Varela-Nieto, I , Del Castillo, I. BMC Genomics - 25 (1) : 359 (PMID: 38605287) (doi:10.1186/s12864-024-10289-z)
29 Sep | 2021 Insulin-like Growth Factor 1 Signaling in Mammalian Hearing. García-Mato, Á , Cervantes, B , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Varela-Nieto, I . Genes (Basel) - 12 (10) (PMID: 34680948) (doi:10.3390/genes12101553)
1 Sep | 2021 Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges. Varela-Nieto, I , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Oset-Gasque, MJ, Marco-Contelles, J. Front Cell Neurosci - 15 : 711269 (PMID: 34539349) (doi:10.3389/fncel.2021.711269)
1 Apr | 2021 Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss. Murillo-Cuesta, S , Celaya, AM , Cervantes, B , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Contreras, J , Sánchez-Pérez, I , Varela-Nieto, I . Clin Transl Med - 11 (4) : e363 (PMID: 33931965) (doi:10.1002/ctm2.363)
14 Oct | 2020 The Value of Mouse Models of Rare Diseases: A Spanish Experience. Murillo-Cuesta, S , Artuch, R, Asensio, F, de la Villa, P, Dierssen, M, Enríquez, JA, Fillat, C, Fourcade, S, Ibáñez, B, Montoliu, L, Oliver, E, Pujol, A, Salido, E, Vallejo, M , Varela-Nieto, I . Front Genet - 11 : 583932 (PMID: 33173540) (doi:10.3389/fgene.2020.583932)
25 Aug | 2020 Drug development for noise-induced hearing loss. Varela-Nieto, I , Murillo-Cuesta, S , Calvino, M, Cediel, R , Lassaletta, L . Expert Opin Drug Discov (PMID: 32838572) (doi:10.1080/17460441.2020.1806232)
14 Sep | 2019 Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity. Cervantes, B , Arana, L, Murillo-Cuesta, S , Bruno, M, Alkorta, I, Varela-Nieto, I . J Clin Med - 8 (9) (PMID: 31540035) (doi:10.3390/jcm8091464)
1 May | 2019 Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia. Partearroyo, T , Murillo-Cuesta, S , Vallecillo, N , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Mandruzzato, G, Celaya, AM , Zeisel, SH, Pajares, MA , Varela-Moreiras, G , Varela-Nieto, I . FASEB J. - 33 (5) : 5942-5956 (PMID: 30753104) (doi:10.1096/fj.201801533R)
2 Apr | 2019 Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Celaya, AM , Sánchez-Pérez, I , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Pintado-Berninches, L , Perona, R , Murillo-Cuesta, S , Varela-Nieto, I . Elife - 8 (PMID: 30938680) (doi:10.7554/eLife.39159)
5 Jul | 2018 MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse. Wesdorp, M, Murillo-Cuesta, S , Peters, T, Celaya, AM , Oonk, A, Schraders, M, Oostrik, J, Gomez-Rosas, E, Beynon, AJ, Hartel, BP, Okkersen, K, Koenen, HJPM, Weeda, J, Lelieveld, S, Voermans, NC, Joosten, I, Hoyng, CB, Lichtner, P, Kunst, HPM, Feenstra, I, de Bruijn, SE, , , Admiraal, RJC, Yntema, HG, van Wijk, E, Del Castillo, I, Serra, P, Varela-Nieto, I , Pennings, RJE, Kremer, H. Am. J. Hum. Genet. - 103 (1) : 74-88 (PMID: 29961571) (doi:10.1016/j.ajhg.2018.05.011)
22 Jan | 2018 Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss. Espino Guarch, M, Font-Llitjós, M, Murillo-Cuesta, S , Errasti-Murugarren, E, Celaya, AM , Girotto, G, Vuckovic, D, Mezzavilla, M, Vilches, C, Bodoy, S, Sahún, I, González, L , Prat, E, Zorzano, A, Dierssen, M, Varela-Nieto, I , Gasparini, P, Palacín, M, Nunes, V. Elife - 7 (PMID: 29355479) (doi:10.7554/eLife.31511)
14 Dec | 2017 The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. García-Alcántara, F , Murillo-Cuesta, S , Pulido, S , Bermúdez-Muñoz, JM , Martínez-Vega, R , Milo, M , Varela-Nieto, I , Rivera, T . Hear. Res. - 358 : 10-21 (PMID: 29304389) (doi:10.1016/j.heares.2017.12.004)
12 Dec | 2017 The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss. Rodríguez-de la Rosa, L , Lassaletta, L , Calvino, M, Murillo-Cuesta, S , Varela-Nieto, I . Front Aging Neurosci - 9 : 411 (PMID: 29311900) (doi:10.3389/fnagi.2017.00411)
8 Mar | 2017 A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection. Murillo-Cuesta, S , Vallecillo, N , Cediel, R , Celaya, AM , Lassaletta, L , Varela-Nieto, I , Contreras, J . J Vis Exp (PMID: 28362376) (doi:10.3791/54951)
1 Sep | 2016 Autophagy resolves early retinal inflammation in Igf1-deficient mice. Arroba, AI , Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Vaquero-Villanueva, L, Hurlé, JM, Varela-Nieto, I , Valverde, ÁM . Dis Model Mech - 9 (9) : 965-974 (PMID: 27483352) (doi:10.1242/dmm.026344)
31 Aug | 2016 Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice. Martínez-Vega, R , Murillo-Cuesta, S , Partearroyo, T , Varela-Moreiras, G , Varela-Nieto, I , Pajares, MA . Front Aging Neurosci - 8 : 209 (PMID: 27630560) (doi:10.3389/fnagi.2016.00209)
1 Mar | 2016 Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei. Fuentes-Santamaría, V, Alvarado, JC, Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Contreras, J , Juiz, JM, Varela-Nieto, I . Brain Struct Funct - 221 (2) : 1205 (PMID: 25416135) (doi:10.1007/s00429-014-0945-z)
1 Mar | 2016 IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei. Fuentes-Santamaría, V, Alvarado, JC, Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Contreras, J , Juiz, JM, Varela-Nieto, I . Brain Struct Funct - 221 (2) : 709-734 (PMID: 25378055) (doi:10.1007/s00429-014-0934-2)
1 Sep | 2015 Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Rodríguez-de la Rosa, L , Sánchez-Calderón, H , Contreras, J , Murillo-Cuesta, S , Falagan, S, Avendaño, C, Dopazo, J, Varela-Nieto, I , Milo, M . Hear. Res. (PMID: 26341476) (doi:10.1016/j.heares.2015.08.016)
12 May | 2015 Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Sanz, L , Murillo-Cuesta, S , Cobo, P, Cediel, R , Contreras, J , Rivera, T , Varela-Nieto, I , Avendaño, C. Front Aging Neurosci - 7 : 79 (PMID: 26029100) (doi:10.3389/fnagi.2015.00079)
8 May | 2015 Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Contreras, J , Celaya, AM , Camarero, G , Rivera, T , Varela-Nieto, I . Front Aging Neurosci - 7 : 72 (PMID: 26005416) (doi:10.3389/fnagi.2015.00072)
20 Mar | 2015 Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Contreras, J , Celaya, AM , Camarero, G , Rivera, T , Varela-Nieto, I . Front Aging Neurosci - 7 : 32 (PMID: 25852546) (doi:10.3389/fnagi.2015.00032)
16 Feb | 2015 Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Sanz, L , Murillo-Cuesta, S , Cobo, P, Cediel-Algovia, R, Contreras, J , Rivera, T , Varela-Nieto, I , Avendaño, C. Front Aging Neurosci - 7 : 7 (PMID: 25762930) (doi:10.3389/fnagi.2015.00007)
4 Feb | 2014 Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice. Rodríguez-de la Rosa, L , López-Herradón, A, Portal-Núñez, S, Murillo-Cuesta, S , Lozano, D, Cediel, R , Varela-Nieto, I , Esbrit, P. PLoS ONE - 9 (2) : e87536 (PMID: 24503961) (doi:10.1371/journal.pone.0087536)
21 Nov | 2013 Programmed cell senescence during mammalian embryonic development. Muñoz-Espín, D, Cañamero, M, Maraver, A, Gómez-López, G, Contreras, J , Murillo-Cuesta, S , Rodríguez-Baeza, A, Varela-Nieto, I , Ruberte, J, Collado, M, Serrano, M. Cell - 155 (5) : 1104-1118 (PMID: 24238962) (doi:10.1016/j.cell.2013.10.019)
1 Jul | 2013 IGF-I deficiency and hearing loss: molecular clues and clinical implications. Varela-Nieto, I , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Lassatetta, L, Contreras, J . Pediatr Endocrinol Rev - 10 (4) : 460-472 (PMID: 23957197)
1 May | 2012 Age-related functional and structural retinal modifications in the Igf1-/- null mouse. Rodriguez-de la Rosa, L , Fernandez-Sanchez, L, Germain, F, Murillo-Cuesta, S , Varela-Nieto, I , de la Villa, P, Cuenca, N. Neurobiol. Dis. - 46 (2) : 476-485 (PMID: 22402333) (doi:10.1016/j.nbd.2012.02.013)
30 Mar | 2012 Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Murillo-Cuesta, S , Camarero, G , González-Rodríguez, A , De La Rosa, LR , Burks, DJ, Avendaño, C, Valverde, AM , Varela-Nieto, I . Mol. Med. - 18 : 260-269 (PMID: 22160220) (doi:10.2119/molmed.2011.00328)
25 Jul | 2011 The role of insulin-like growth factor-I in the physiopathology of hearing. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Cediel, R , Lassaletta, L , Varela-Nieto, I . Front Mol Neurosci - 4 : 11 (PMID: 21845174) (doi:10.3389/fnmol.2011.00011)
23 Jun | 2010 A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. Riquelme, R , Cediel, R , Contreras, J , la Rosa Lourdes, RD , Murillo-Cuesta, S , Hernandez-Sanchez, C, Zubeldia, JM , Cerdan, S , Varela-Nieto, I . Front Neuroanat - 4 : 27 (PMID: 20661454) (doi:10.3389/fnana.2010.00027)
1 Apr | 2010 Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Murillo-Cuesta, S , Contreras, J , Cediel, R , Varela-Nieto, I . Lab. Anim. - 44 (2) : 124-131 (PMID: 19858169) (doi:10.1258/la.2009.009046)
1 Feb | 2010 Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Murillo-Cuesta, S , Contreras, J , Zurita, E, Cediel, R , Cantero, M, Varela-Nieto, I , Montoliu, L. Pigment Cell Melanoma Res - 23 (1) : 72-83 (PMID: 19843244) (doi:10.1111/j.1755-148X.2009.00646.x)
24 Nov | 2009 Direct drug application to the round window: a comparative study of ototoxicity in rats. Murillo-Cuesta, S , García-Alcántara, F , Vacas, E , Sistiaga, JA, Camarero, G , Varela-Nieto, I , Rivera, T . Otolaryngol Head Neck Surg - 141 (5) : 584-590 (PMID: 19861195) (doi:10.1016/j.otohns.2009.07.014)
12 Feb | 2008 [Neurotrophic action of insulin-like growth factor-I in the inner ear]. Rodríguez-de la Rosa, L , Contreras-Rodríguez, J , Cediel-Algovia, R , León, Y , Sánchez-Calderón, H , Murillo-Cuesta, S , Riquelme-Galiana, R , de Diego-Sastre, JI , Prim-Espada, MP , Varela-Nieto, I , , . Rev Neurol - 45 (4) : 245-250 (PMID: 17668408)