1 Nov | 2025 A Sensitive Radioimmunoassay for T3 and T4 Determinations in Plasma and Tissues. Montero-Pedrazuela, A , Grijota-Martínez, C , Guadaño-Ferraz, A , Bárez-López, S . Methods Mol Biol - 2876 : 37-59 (PMID: 39579307) (doi:10.1007/978-1-0716-4252-8_3)
1 Nov | 2025 Magnetic Resonance Imaging Techniques for Investigating the MCT8-Deficient Brain in Murine Disease Models. Guillén-Yunta, M , Guadaño-Ferraz, A , Valcárcel-Hernández, V . Methods Mol Biol - 2876 : 175-186 (PMID: 39579316) (doi:10.1007/978-1-0716-4252-8_12)
1 Aug | 2024 Defective thyroid hormone transport to the brain leads to astroglial alterations. Guillén-Yunta, M , García-Aldea, Á , Valcárcel-Hernández, V , Sanz-Bógalo, A , Muñoz-Moreno, E, Matheus, MG, Grijota-Martínez, C , Montero-Pedrazuela, A , Guadaño-Ferraz, A , Bárez-López, S . Neurobiol Dis (PMID: 39097035) (doi:10.1016/j.nbd.2024.106621)
18 Jun | 2024 Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Valcárcel-Hernández, V , Vancamp, P, Butruille, L, Remaud, S, Guadaño-Ferraz, A . Neurobiol Dis (PMID: 38901782) (doi:10.1016/j.nbd.2024.106572)
7 Mar | 2024 Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Valcárcel-Hernández, V, Mayerl, S, Guadaño-Ferraz, A , Remaud, S. Front Endocrinol (Lausanne) - 15 : 1347802 (PMID: 38516412) (doi:10.3389/fendo.2024.1347802)
1 Feb | 2024 Insights on the role of thyroid hormone transport in neurosensory organs and implication for Allan-Herndon-Dudley syndrome. García-Aldea, Á , Guillén-Yunta, M , Valcárcel-Hernández, V , Montero-Pedrazuela, A , Guadaño-Ferraz, A , Bárez-López, S . Eur Thyroid J (PMID: 38417253) (doi:10.1530/ETJ-23-0241)
3 Nov | 2023 Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency. Guillén-Yunta, M , Valcárcel-Hernández, V , García-Aldea, Á , Soria, G, García-Verdugo, JM, Montero-Pedrazuela, A , Guadaño-Ferraz, A . Fluids Barriers CNS - 20 (1) : 79 (PMID: 37924081) (doi:10.1186/s12987-023-00481-w)
1 Jun | 2023 Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains. Wang, T, Wang, Y, Montero-Pedrazuela, A , Prensa, L, Guadaño-Ferraz, A , Rausell, E. Int J Mol Sci - 24 (11) (PMID: 37298594) (doi:10.3390/ijms24119643)
15 Feb | 2023 Maternal administration of the CNS-selective sobetirome prodrug Sob-AM2 exerts thyromimetic effects in murine MCT8-deficient fetuses. Valcárcel Hernández, V , Guillén Yunta, M , Scanlan, T, Bárez-López, S , Guadaño-Ferraz, A . Thyroid (PMID: 36792926) (doi:10.1089/thy.2022.0612)
6 Feb | 2023 Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain. Wang, Y, Wang, T, Montero-Pedrazuela, A , Guadaño-Ferraz, A , Rausell, E. Int J Mol Sci - 24 (4) (PMID: 36834621) (doi:10.3390/ijms24043207)
17 Jan | 2023 Intracerebroventricular High Doses of 3,3',5-Triiodothyroacetic Acid at Juvenile Stages Improve Peripheral Hyperthyroidism and Mediate Thyromimetic Effects in Limited Brain Regions in a Mouse Model of Monocarboxylate Transporter 8 Deficiency. Grijota-Martínez, C , Montero-Pedrazuela, A , Hidalgo-Álvarez, J , Bárez-López, S , Guadaño-Ferraz, A . Thyroid (PMID: 36565029) (doi:10.1089/thy.2022.0562)
12 Oct | 2022 A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations. Valcárcel-Hernández, V , Guillén-Yunta, M , Bueno-Arribas, M , Montero-Pedrazuela, A , Grijota-Martínez, C , Markossian, S, García-Aldea, Á , Flamant, F, Bárez-López, S , Guadaño-Ferraz, A . Neurobiol Dis (PMID: 36243247) (doi:10.1016/j.nbd.2022.105896)
24 Nov | 2021 Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development. Valcárcel-Hernández, V , López-Espíndola, D , Guillén-Yunta, M , García-Aldea, Á , de Toledo-Soler, IL , Bárez-López, S , Guadaño-Ferraz, A . Neurobiol Dis (PMID: 34838669) (doi:10.1016/j.nbd.2021.105567)
10 Oct | 2020 Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue. Escalona-Garrido, C , Vázquez, P , Mera, P, Zagmutt, S, García-Casarrubios, E , Montero-Pedrazuela, A , Rey-Stolle, F, Guadaño-Ferraz, A , Rupérez, FJ, Serra, D, Herrero, L, Obregon, MJ , Valverde, ÁM . Mol Metab (PMID: 33049408) (doi:10.1016/j.molmet.2020.101097)
20 Jul | 2020 Intranasal delivery of Thyroid hormones in MCT8 deficiency. Grijota-Martínez, C , Bárez-López, S , Ausó, E , Refetoff, S , Frey, WH, Guadaño-Ferraz, A . PLoS ONE - 15 (7) : e0236113 (PMID: 32687511) (doi:10.1371/journal.pone.0236113)
28 Apr | 2020 MCT8 Deficiency: The Road to Therapies for a Rare Disease. Grijota-Martínez, C , Bárez-López, S , Gómez-Andrés, D, Guadaño-Ferraz, A . Front Neurosci - 14 : 380 (PMID: 32410949) (doi:10.3389/fnins.2020.00380)
6 Dec | 2019 Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8. Bárez-López, S , Grijota-Martínez, C , Liao, XH, Refetoff, S , Guadaño-Ferraz, A . PLoS ONE - 14 (12) : e0226017 (PMID: 31809508) (doi:10.1371/journal.pone.0226017)
30 Jul | 2019 Adult mice lacking Mct8 and Dio2 proteins present alterations in peripheral thyroid hormone levels and severe brain and motor skill impairments. Bárez-López, S , Grijota-Martínez, C , Ausó, E , Fernández-de Frutos, M, Montero-Pedrazuela, A , Guadaño-Ferraz, A . Thyroid (PMID: 31359845) (doi:10.1089/thy.2019.0068)
1 Jul | 2019 Thyroid hormone availability in the human fetal brain: novel entry pathways and role of radial glia. López-Espíndola, D , García-Aldea, Á , Gómez de la Riva, I, Rodríguez-García, AM, Salvatore, D, Visser, TJ, Bernal, J , Guadaño-Ferraz, A . Brain Struct Funct - 224 (6) : 2103-2119 (PMID: 31165302) (doi:10.1007/s00429-019-01896-8)
3 Apr | 2019 Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits. Ordás, P, Hernández-Ortego, P, Vara, H, Fernández-Peña, C, Reimúndez, A, Morenilla-Palao, C, Guadaño-Ferraz, A , Gomis, A, Hoon, M, Viana, F, Señarís, R. J. Comp. Neurol. (PMID: 30942489) (doi:10.1002/cne.24694)
30 May | 2018 Sobetirome and its amide prodrug Sob-AM2 exert thyromimetic actions in Mct8-deficient brain. Bárez-López, S , Hartley, MD, Grijota-Martínez, C , Scanlan, T, Guadaño-Ferraz, A . Thyroid (PMID: 29845892) (doi:10.1089/thy.2018.0008)
1 May | 2018 Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development. Bárez-López, S , Obregon, MJ , Bernal, J , Guadaño-Ferraz, A . Cereb. Cortex - 28 (5) : 1783-1793 (PMID: 28407057) (doi:10.1093/cercor/bhx088)
1 Oct | 2017 Increased anxiety and fear memory in adult mice lacking type 2 deiodinase. Bárez-López, S , Montero-Pedrazuela, A , Bosch-García, D , Venero, C, Guadaño-Ferraz, A . Psychoneuroendocrinology - 84 : 51-60 (PMID: 28654773) (doi:10.1016/j.psyneuen.2017.06.013)
14 Aug | 2017 Thyroid Hormone Availability and Action during Brain Development in Rodents. Bárez-López, S , Guadaño-Ferraz, A . Front Cell Neurosci - 11 : 240 (PMID: 28855863) (doi:10.3389/fncel.2017.00240)
1 May | 2017 The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors. España-Serrano, L, Guerra Martín-Palanco, N, Montero-Pedrazuela, A , Pérez-Santamarina, E, Vidal, R, García-Consuegra, I, Valdizán, EM, Pazos, A, Palomo, T, Jiménez-Arriero, MÁ, Guadaño-Ferraz, A , Hoenicka, J. Cereb. Cortex - 27 (5) : 2809-2819 (PMID: 27166167) (doi:10.1093/cercor/bhw129)
18 Jul | 2016 Adeno associated virus 9-based gene therapy delivers a functional monocarboxylate transporter 8 (MCT8) which improves thyroid hormone availability to brain of Mct8 deficient mice. Iwayama, H, Liao, XH, Braun, L, Bárez-López, S , Kaspar, B, Weiss, R, Dumitrescu, AM, Guadaño-Ferraz, A , Refetoff, S . Thyroid (PMID: 27432638) (doi:10.1089/thy.2016.0060)
1 May | 2016 Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution. Bárez-López, S , Obregon, MJ , Martínez-de-Mena, R , Bernal, J , Guadaño-Ferraz, A , Morte, B . Thyroid - 26 (5) : 618-626 (PMID: 26701289) (doi:10.1089/thy.2015.0388)
1 Dec | 2015 Thyroid hormone transporters-functions and clinical implications. Bernal, J , Guadaño-Ferraz, A , Morte, B . Nat Rev Endocrinol - 11 (12) : 690 (PMID: 26485690) (doi:10.1038/nrendo.2015.186)
1 Sep | 2015 Thyroid hormone transporters--functions and clinical implications. Bernal, J , Guadaño-Ferraz, A , Morte, B . Nat Rev Endocrinol - 11 (9) : 506 (PMID: 26149615) (doi:10.1038/nrendo.2015.113)
1 Jul | 2015 Thyroid hormone transporters--functions and clinical implications. Bernal, J , Guadaño-Ferraz, A , Morte, B . Nat Rev Endocrinol - 11 (7) : 406-417 (PMID: 25942657) (doi:10.1038/nrendo.2015.66)
6 Dec | 2014 Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination. López-Espíndola, D , Morales-Bastos, C, Grijota-Martínez, C , Liao, XH, Lev, D, Sugo, E, Verge, CF, Refetoff, S , Bernal, J , Guadaño-Ferraz, A . J. Clin. Endocrinol. Metab. - 99 (12) : E2799-804 (PMID: 25222753) (doi:10.1210/jc.2014-2162)
1 Aug | 2014 Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase. Bárez-López, S , Bosch-García, D , Gómez-Andrés, D, Pulido-Valdeolivas, I, Montero-Pedrazuela, A , Obregon, MJ , Guadaño-Ferraz, A . PLoS ONE - 9 (8) : e103857 (PMID: 25083788) (doi:10.1371/journal.pone.0103857)
24 Oct | 2011 Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala. Montero-Pedrazuela, A , Fernández-Lamo, I , Alieva, M , Pereda-Pérez, I, Venero, C, Guadaño-Ferraz, A . PLoS ONE - 6 (10) : e26582 (PMID: 22039511) (doi:10.1371/journal.pone.0026582)
3 Aug | 2009 Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats. Fernández-Lamo, I , Montero-Pedrazuela, A , Delgado-García, JM, Guadaño-Ferraz, A , Gruart, A. Eur. J. Neurosci. - 30 (4) : 679-692 (PMID: 19686470) (doi:10.1111/j.1460-9568.2009.06862.x)
1 Apr | 2006 Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior. Montero-Pedrazuela, A , Venero, C, Lavado-Autric, R , Fernández-Lamo, I , García-Verdugo, JM, Bernal, J , Guadaño-Ferraz, A . Mol Psychiatry - 11 (4) : 361-371 (PMID: 16446739) (doi:10.1038/sj.mp.4001802)
1 Mar | 2006 Generation and characterization of dickkopf3 mutant mice. Barrantes, Idel B, Montero-Pedrazuela, A , Guadaño-Ferraz, A , Obregon, MJ , Martinez de Mena, R , Gailus-Durner, V, Fuchs, H, Franz, TJ, Kalaydjiev, S, Klempt, M, Hölter, S, Rathkolb, B, Reinhard, C, Morreale de Escobar, G , Bernal, J , Busch, DH, Wurst, W, Wolf, E, Schulz, H, Shtrom, S, Greiner, E, Hrabé de Angelis, M, Westphal, H, Niehrs, C. Mol. Cell. Biol. - 26 (6) : 2317-2326 (PMID: 16508007) (doi:10.1128/MCB.26.6.2317-2326.2006)
26 Dec | 2005 RC3/neurogranin is expressed in pyramidal neurons of motor and somatosensory cortex in normal and denervated monkeys. Guadaño-Ferraz, A , Viñuela, A, Oeding, G, Bernal, J , Rausell, E. J. Comp. Neurol. - 493 (4) : 554-570 (PMID: 16304627) (doi:10.1002/cne.20774)
15 Sep | 2005 Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment. Venero, C, Guadaño-Ferraz, A , Herrero, AI, Nordström, K , Manzano, J , de Escobar, GM, Bernal, J , Vennström, B . Genes Dev - 19 (18) : 2152-2163 (PMID: 16131613) (doi:10.1101/gad.346105)
1 Oct | 2004 Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. Martin, G, Guadaño-Ferraz, A , Morte, B , Ahmed, S, Koob, GF, De Lecea, L, Siggins, GR. J. Pharmacol. Exp. Ther. - 311 (1) : 265-273 (PMID: 15263066) (doi:10.1124/jpet.104.067504)
1 Oct | 2004 Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development. Quignodon, L, Legrand, C, Allioli, N, Guadaño-Ferraz, A , Bernal, J , Samarut, J, Flamant, F. J. Mol. Endocrinol. - 33 (2) : 467-476 (PMID: 15525602) (doi:10.1677/jme.1.01570)
1 Nov | 2003 Perspectives in the study of thyroid hormone action on brain development and function. Bernal, J , Guadaño-Ferraz, A , Morte, B . Thyroid - 13 (11) : 1005-1012 (PMID: 14651784) (doi:10.1089/105072503770867174)
28 Mar | 2003 Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins. Montero-Pedrazuela, A , Bernal, J , Guadaño-Ferraz, A . Endocrinology - 144 (3) : 1045-1052 (PMID: 12586781) (doi:10.1210/en.2002-220823)
30 Jan | 2003 Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits. Guadaño-Ferraz, A , Benavides-Piccione, R, Venero, C, Lancha, C, Vennström, B , Sandi, C, DeFelipe, J, Bernal, J . Mol. Psychiatry - 8 (1) : 30-38 (PMID: 12556906) (doi:10.1038/sj.mp.4001196)
3 Jul | 2002 Analysis of thyroid hormone-dependent genes in the brain by in situ hybridization. Bernal, J , Guadaño-Ferraz, A . Methods Mol. Biol. - 202 : 71-90 (PMID: 12094608) (doi:10.1385/1-59259-174-4:71)
22 Nov | 1999 Type 3 iodothyronine deiodinase is selectively expressed in areas related to sexual differentiation in the newborn rat brain. Escámez, MJ , Guadaño-Ferraz, A , Cuadrado, A , Bernal, J . Endocrinology - 140 (11) : 5443-5446 (PMID: 10537178) (doi:10.1210/endo.140.11.7244)
8 Sep | 1999 Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate. Calbet, M, Guadaño-Ferraz, A , Spier, AD, Maj, M, Sutcliffe, JG, Przewłocki, R, de Lecea, L. Brain Res. Mol. Brain Res. - 72 (1) : 55-64 (PMID: 10521599)
1 May | 1999 Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. Guadaño-Ferraz, A , Escámez, MJ , Rausell, E, Bernal, J . J. Neurosci. - 19 (9) : 3430-3439 (PMID: 10212303)
3 Oct | 1997 Transcriptional induction of RC3/neurogranin by thyroid hormone: differential neuronal sensitivity is not correlated with thyroid hormone receptor distribution in the brain. Guadaño-Ferraz, A , Escámez, MJ , Morte, B , Vargiu, P , Bernal, J . Brain Res. Mol. Brain Res. - 49 (1-2) : 37-44 (PMID: 9387861)
16 Sep | 1997 The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Guadaño-Ferraz, A , Obregón, MJ , St Germain, DL, Bernal, J . Proc. Natl. Acad. Sci. U.S.A. - 94 (19) : 10391-10396 (PMID: 9294221)
1 Mar | 1996 Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Iniguez, MA, De Lecea, L, Guadano-Ferraz, A , Morte, B , Gerendasy, D, Sutcliffe, JG, Bernal, J . Endocrinology - 137 (3) : 1032-1041 (PMID: 8603571) (doi:10.1210/endo.137.3.8603571)
30 Jun | 1995 Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes. Velaz-Faircloth, M, Guadaño-Ferraz, A , Henzi, VA, Fremeau, RT. J. Biol. Chem. - 270 (26) : 15755-15761 (PMID: 7797577)
20 Oct | 1994 Role of thyroid hormones in the maturation of interhemispheric connections in rats. Berbel, P, Guadaño-Ferraz, A , Angulo, A, Ramón Cerezo, J. Behav. Brain Res. - 64 (1-2) : 9-14 (PMID: 7840896)
16 Sep | 1994 The development of the anterior commissure in normal and hypothyroid rats. Guadaño Ferraz, A , Escobar del Rey, F , Morreale de Escobar, G , Innocenti, GM, Berbel, P. Brain Res. Dev. Brain Res. - 81 (2) : 293-308 (PMID: 7813049)
1 Dec | 1993 Molecular characterization of neurotransmitter transporters. Shafqat, S, Velaz-Faircloth, M, Guadaño-Ferraz, A , Fremeau, RT. Mol. Endocrinol. - 7 (12) : 1517-1529 (PMID: 7908408) (doi:10.1210/mend.7.12.7908408)
1 Nov | 1993 Organization of auditory callosal connections in hypothyroid adult rats. Berbel, P, Guadaño-Ferraz, A , Martínez, M, Quiles, JA, Balboa, R, Innocenti, GM. Eur. J. Neurosci. - 5 (11) : 1465-1478 (PMID: 7506971)
25 Jul | 1993 Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. Shafqat, S, Tamarappoo, BK, Kilberg, MS, Puranam, RS, McNamara, JO, Guadaño-Ferraz, A , Fremeau, RT. J. Biol. Chem. - 268 (21) : 15351-15355 (PMID: 8340364)
1 Nov | 1990 Developmental changes in the heavy subunit of neurofilaments in the corpus callosum of the cat. Guadano-Ferraz, A , Riederer, BM, Innocenti, GM. Brain Res. Dev. Brain Res. - 56 (2) : 244-256 (PMID: 2124524)
1 Nov | 1990 Difference in distribution of microtubule-associated proteins 5a and 5b during the development of cerebral cortex and corpus callosum in cats: dependence on phosphorylation. Riederer, BM, Guadano-Ferraz, A , Innocenti, GM. Brain Res. Dev. Brain Res. - 56 (2) : 235-243 (PMID: 2261685)