About the Group:

Molecular and Redox Dynamics and Therapeutical Targets in Diseases is a multidisciplinary research group focused on understanding the molecular mechanisms underlying human diseases and identifying innovative therapeutic targets. The group integrates expertise in redox biology, metabolism, molecular biochemistry and biophysics, membrane dynamics, neurodegeneration and translational biotechnology. The scientific leadership combines the complementary experience of Prof. Alejandro K. Samhan Arias, Prof. Óscar H. Martínez-Costa, both researchers from the Department of Biochemistry at the Universidad Autónoma de Madrid and the Institute for Biomedical Research Sols-Morreale (IIBM).

The group combines fundamental and translational approaches, spanning from structural and biochemical characterization of proteins to cellular, animal, and preclinical models. Through this strategy, we seek to transform mechanistic discoveries into therapeutic opportunities capable of improving disease prevention, diagnosis, and treatment.

Research lines:

• Membrane Dynamics and Neurodegeneration: A research line in this group focuses on the organization and function of neuronal membrane nanodomains, as environments where redox-active components cluster with proteins in charge of calcium homeostasis to form calcium microchip-like structures. We also investigate how caveolins, cholesterol metabolism, membrane nanodomain formation, and signaling pathways influence neuronal function and disease progression. Our objective is to identify molecular mechanisms linking membrane organization to Alzheimer's disease and other neurodegenerative disorders, ultimately enabling the development of novel therapeutic interventions targeting membrane-associated pathological processes.
• Redox Dynamics and Hysteresis: We investigate how redox signaling networks, membrane organization, and metabolic adaptation generate cellular memory and hysteretic responses that influence disease susceptibility and progression. By understanding how cells transition between physiological and pathological states, we aim to identify novel therapeutic strategies capable of restoring redox resilience in neurodegenerative, metabolic and age-related diseases. From a bioelectronics perspective, the team applies electrochemistry at biomimetic and biological interfaces to dissect electron transfer pathways. The team has also developed bioelectronic devices, sensors, and wearables to monitor molecules in biofluids under physiological and disease.

Master students | PhD students | Post-Doctoral

Positions for fellows are permanently open.
Our group welcomes highly motivated graduates and PhD holders to undertake research with us.
Feel free to contact us