The Brain Structure and Function journal publishes a paper codirected by Drs. Isabel Varela-Nieto and Dr. Jose Manuel Juiz (Castilla la Mancha University) that deeps into the morphologic and physiologic alterations of the cochlear nucleus, the first step in the central auditive pathway, in mice with Insulin-like growth factor 1 (IGF-1) deficiency. This study confirms that Igf1 knockout mice present changes in the cochlear nucleus cytoarchitecture as well as in the expression of VGluT1 and VGAT transporters, and MEF2 transcription factor.
Fuentes-Santamaría V, Alvarado JC, Rodríguez-de la Rosa L, Murillo-Cuesta S, Contreras J, Juiz JM, Varela-Nieto I. IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei. Brain Struct Funct. 2014 Nov 7.