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The Experimental Multimodal Imaging Service (SIME) is a facility of Preclínical Multimodal Imaging for small animals. It is located in the Instituto de Investigaciones Biomédicas CSIC-UAM (IIB), and is part of the Multimodal Biomaging Module for small animals integrated in the INNOTEK platform of the Academic Excellence Campus CSIC-UAM: Advanced techniques for the generation and characterization of animal models.

Given the characteristics of the materials employed, SIME is part of the Radioactive Installation of the IIB, authorized by the Dirección General de Industria y Energía of the Consejería de Economía e Innovación Tecnológica, with authorization number: IR/M-423/89.

SIME has a trimodal scanner INVEON, (microCT-microSPECT-microPET) from SIEMENS for small animals (mice and rats), the first one installed in Spain. The INVEON system, due to its characteristics, provides high quality PET, SPECT and CT data.

Molecular imaging techniques, like PET (Positron Emission Tomography) and SPECT (Single Photon Emission Computed Tomography), allow visual representation, characterization and quantification of biological processes at cellular and molecular level in living organisms without perturbing the system under study. For this purpose, an appropriate radiotracer is administered to the animal. X-ray Computed Tomography (CT) provides morphological (anatomical) information, complementary to the metabolic data supplied by microPET-microSPECT.

The authorized radioisotopes for multimodal imaging studies are:

 

Radionucleid

Simbol

Half-life

Studies

Tecnetium-99m

99Tc

6 hours

SPECT

Iodine-123

123I

13.2 hours

SPECT

Thallium-201

201Tl

3.04 days

SPECT

Gallium-67

67Ga

3.26 days

SPECT

Fluoride-18

18F

109.8 min

PET

Carbon-11

11C

20.4 min

PET

Cupper-64

64Cu

12.7 hours

PET

Rubidium-82

82Rb

1.3 min

PET

Gallium-68

68Ga

1.13 hours

PET

Iodine-124

124I

4.18 days

PET

Bromine-76

76Br

16.2 hours

PET