News

Research: the key to progress in the diagnosis and treatment of hypoacusis

An outreach event entitled "Research: the key to progress in the diagnosis and treatment of hypoacusis" was held on March 10 , on the occasion of World Hearing Day. This online activity - broadcast live and accessible to people with hearing impairment - was attended by a representative of the Word Health Organization, who presented for the first time the 2021 WHO World Hearing Report, with alarming data on the prevalence of hearing problems and estimates of an increase in the coming decades. This presentation was followed by an interesting colloquium on hearing loss research with representatives from the World Health Organization, hearing loss patient associations, pharmaceutical companies, clinicians and basic researchers. To conclude the event, an outreach video directed to raise public awareness of hearing loss, was displayed. This event was...

World Rare Disease Day

February 28th, World Rare Disease Day. Drs. Ricardo Escalante and Oliver Vincent. Laboratory for the study of the molecular mechanisms of autophagy Autophagy is an intracellular degradation mechanism essential for cellular homeostasis, differentiation and development. Recent research has highlighted the impact of autophagy in neurodegenerative diseases and aging. Our laboratories use different model systems including the yeast Saccharomyces cerevisiae, the social amoeba Dictyostelium discoideum and mammalian cells in culture to understand the molecular mechanisms of two rare neurodegenerative diseases: chorea-acanthocytosis (ChAc) and Beta-propeller protein-associated neurodegeneration (BPAN), in which autophagy dysfunction may play a relevant role. These diseases are devastating and incurable leading to neurodegeneration with severe movement, psychiatric dysfunction...

IIBM researcher Alicia González-Martín receives funding from the Spanish Association Against Cancer for a project on cancer immunotherapy

The Spanish Association Against Cancer (AECC) will support the doctor's laboratory in the development of an innovative in vivo functional screen strategy to identify new therapeutic targets.     The Spanish Association Against Cancer (AECC) has awarded funding to the laboratory of Dr. Alicia González-Martín for a project that aims to identify new therapeutic targets for cancer immunotherapy, within the latest call for projects LAB AECC 2020.   According to the researcher from the Institute for Biomedical Research Alberto Sols, her team is interested on "understanding the molecular mechanisms that regulate the immune system in health and disease, and one of our main lines of research focuses on in studying immune responses against cancer. The cells of our immune system not only defend us against infections by...

Farewell to Professor Carlos Gancedo on the occasion of his retirement.

On December 18, on the occasion of his retirement after 57 years of service, Professor Carlos Gancedo gave in the auditorium of the Alberto Sols Biomedical Research Institute the lecture entitled "Releasing ties" ("Soltando amarras"). Carlos Gancedo has been part of our center since its inception. He moved from the CSIC's Center for Biological Research in the mid-sixties of the last century with Alberto Sols, under whose direction he did his doctoral thesis, to establish the Institute of Enzymology, an embryo of the IIBM. Since then, his professional career has been a show of dedication and love for science and knowledge, practicing in recent years as Professor of the CSIC linked ad honorem. It is an international reference in the biochemistry, molecular biology and genetics of yeasts, and has thus been recognized for many years with the...

Call for applications GARANTÍA JUVENIL 2020 (Ref. 37722)

Applications to the GARANTÍA JUVENIL 2020 call  (Ref. 37722), published in the CSIC's web site, are now opwn. Contracts are offered for technicians, aimed at young people who are not employed and who are not studying or in training, through the Youth Employment Initiative and the European Social Fund. Those interested in participating in the selection process may applt during a period of 10 working days to submit their applications (from January 15 to 28, both inclusive) . Those who wish to participate in the selection process must access the electronic application enabled for this purpose at the CSIC's electronic headquarters, within the publication of the call, and fill in the application form (Annex II button). Once the request is made effective electronically, a .pdf document (Annex II) will be generated that must be printed and...

IIBm researchers discover a new way to grow cancer stem cells from pancreatic cancer

Dr. Bruno Sainz's research team ( www.sainzlab.com ), supported by the Spanish Association Against Cancer (AECC) and the Carmen Delgado/Miguel Pérez-Mateo Fellowship from AESPANC-ACANPAN, has published a new study in Nature Communications ( https://www.nature.com/articles/s41467-020-18954- z ) where they manage to cultivate, in a sustainable way, pancreatic cancer stem cells, the most aggressive cell type present within pancreatic cancer. The study, led by first author Dr. Sandra Valle, represents an important advance that should facilitate the identification of new targets and therapies against this tumor and these cells in particular. Cancer stem cells are one of the key cancer cell types that mediate tumor survival, as they are able to resist common chemotherapy and thus drive tumor relapse...

Cholesterolnitrones, a new family of antioxidant molecules for the treatment of hearing loss

The Neurobiology of Hearing group, led by Prof. Isabel Varela Nieto, will carry out trials in cellular and animal models throughout 2021 to evaluate the efficacy of cholesterolnithrones in the treatment of presbicusis and hearing loss associated to cisplatin ototoxicity. These small molecules are potent antioxidant agents which have shown a strong neuroprotective effect in in vitro studies, in neuronal primary cultures and in animal models of global and focal brain ischemia in rats and mice. The results of this works will be critical to confirm the potential of this molecule as a compound-lead for entry into the preclinical phase.   This project, in which the Medical Chemistry Laboratory of the Institute of General Organic Chemistry of the CSIC is also participating, led by Prof. José Luis Marco Contelles, has been selected by the Fundación General CSIC ...

A possible new therapy for pancreatic cancer

A study carried out with the participation of the team led by Dr. Bruno Sainz, Jr., a researcher at the "Alberto Sols" Biomedical Research Institute (IIBM-UAM) and supported by the Spanish Association Against Cancer (AECC), has identified a new Achilles' heel of pancreatic cancer stem cells: a part of the cell known as lysosomes, which represents a possible target for treating this type of cancer, one of the most aggressive of all malignancies.   Pancreatic cancer is a cancer that responds poorly to available treatments, due in part to the presence of cancer stem cells. This type of cell has the capacity to give rise to all of the other cancer cells present within the tumor and they are responsible for the origin of the tumor, its spread to other organs or metastasis, and relapse.    In order to find new...

The UAM, the IIBM (CSIC-UAM) and the FPCM receive the validation to carry out diagnostic PCR tests for Covid19

El Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), centro mixto del Consejo Superior de Investigaciones Científicas (CSIC) y la Universidad Autónoma de Madrid (UAM), ha recibido la validación del Instituto de Salud Carlos III, dependiente del Ministerio de Ciencia e Innovación, para realizar las pruebas PCR de detección molecular del coronavirus SARS-CoV-2, causante de la pandemia de Covid-19. https://www.csic.es/es/actualidad-del-csic/la-uam-el-iibm-csic-uam-y-la-fpcm-reciben-la-validacion-para-realizar-pruebas