We are searching for genes participating in neoplastic transformation that may become therapeutic targets. To this end, we compare the transcriptomes of transformed and immortalized cells. We assess the contribution of these genes to the progression of immortalized cells to a transformed state using both cell and animal models. We also search for genes mediating pathological vascular wall remodeling, a key process in the development of hypertension, atherosclerosis, aneurysm and restenosis. We determine the contribution of these genes to vessel remodeling using mouse models for these pathologies, primary cells cultures and numerous approaches based in molecular and cell biology.