Publications
Articles Published in   Isabel Lastres Becker   

1.- Galán-Ganga, M , García-Yagüe, ÁJ , Lastres-Becker, I . (2019). Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells. Cell. Mol. Neurobiol. 39(3): 331-340 (PMID: 30830503) Abstract
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2.- Castro-Sánchez, S , García-Yagüe, ÁJ , Kügler, S, Lastres-Becker, I . (2019). CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies. Redox Biol. 22: 101118 (PMID: 30769286) Abstract
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3.- Castro-Sánchez, S , García-Yagüe, ÁJ , López-Royo, T , Casarejos, M, Lanciego, JL, Lastres-Becker, I . (2018). Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease. Glia. (PMID: 29624735) Abstract
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4.- Cuadrado, A , Kügler, S, Lastres-Becker, I . (2017). Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol. 14: 522-534 (PMID: 29121589) Abstract
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5.- Lastres-Becker, I , Nonis, D, Eich, F, Klinkenberg, M, Gorospe, M, Kötter, P, Klein, FA, Kedersha, N, Auburger, G. (2016). Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation. Biochim. Biophys. Acta. 1862(9): 1558-1569 (PMID: 27240544) Abstract
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6.- Lastres-Becker, I , García-Yagüe, AJ, Scannevin, RH, Casarejos, MJ, Kügler, S, Rábano, A, Cuadrado, A . (2016). Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease. Antioxid. Redox Signal. 25(2): 61-77 (PMID: 27009601) Abstract
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7.- Fittschen, M, Lastres-Becker, I , Halbach, MV, Damrath, E, Gispert, S, Azizov, M, Walter, M, Müller, S, Auburger, G. (2015). Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate. Neurogenetics. 16(3): 181-192 (PMID: 25721894) Abstract
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8.- Delgado-Buenrostro, NL, Medina-Reyes, EI, Lastres-Becker, I , Freyre-Fonseca, V, Ji, Z, Hernández-Pando, R, Marquina, B, Pedraza-Chaverri, J, Espada, S , Cuadrado, A , Chirino, YI. (2015). Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release. Environ. Toxicol. 30(7): 782-792 (PMID: 24615891) Abstract
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9.- Cuadrado, A , Martín-Moldes, Z, Ye, J, Lastres-Becker, I . (2014). Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation. J. Biol. Chem. 289(22): 15244-15258 (PMID: 24759106) Abstract
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10.- Lastres-Becker, I , Innamorato, NG , Jaworski, T, Rábano, A, Kügler, S, Van Leuven, F, Cuadrado, A . (2014). Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain. 137(Pt 1): 78-91 (PMID: 24277722) Abstract
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11.- Martín-de-Saavedra, MD, Budni, J, Cunha, MP, Gómez-Rangel, V, Lorrio, S, Del Barrio, L, Lastres-Becker, I , Parada, E, Tordera, RM, Rodrigues, AL, Cuadrado, A , López, MG. (2013). Nrf2 participates in depressive disorders through an anti-inflammatory mechanism. Psychoneuroendocrinology. 38(10): 2010-2022 (PMID: 23623252) Abstract
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12.- Drost, J, Nonis, D, Eich, F, Leske, O, Damrath, E, Brunt, ER, Lastres-Becker, I , Heumann, R, Nowock, J, Auburger, G. (2013). Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling. J. Mol. Neurosci. 51(1): 68-81 (PMID: 23335000) Abstract
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13.- García-Yagüe, ÁJ, Rada, P , Rojo, AI , Lastres-Becker, I , Cuadrado, A . (2013). Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. J. Biol. Chem. 288(8): 5506-5517 (PMID: 23283970) Abstract
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14.- Lastres-Becker, I , Ulusoy, A, Innamorato, NG , Sahin, G, Rábano, A, Kirik, D, Cuadrado, A . (2012). α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Hum. Mol. Genet. 21(14): 3173-3192 (PMID: 22513881) Abstract
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15.- Granado, N, Lastres-Becker, I , Ares-Santos, S, Oliva, I, Martin, E, Cuadrado, A , Moratalla, R. (2011). Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia. 59(12): 1850-1863 (PMID: 21882243) Abstract
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16.- Kurz, A, Double, KL, Lastres-Becker, I , Tozzi, A, Tantucci, M, Bockhart, V, Bonin, M, García-Arencibia, M, Nuber, S, Schlaudraff, F, Liss, B, Fernández-Ruiz, J, Gerlach, M, Wüllner, U, Lüddens, H, Calabresi, P, Auburger, G, Gispert, S. (2010). A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS ONE. 5(7): e11464 (PMID: 20628651) Abstract
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17.- Niso-Santano, M, González-Polo, RA, Bravo-San Pedro, JM, Gómez-Sánchez, R, Lastres-Becker, I , Ortiz-Ortiz, MA, Soler, G, Morán, JM, Cuadrado, A , Fuentes, JM, , . (2010). Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. Free Radic. Biol. Med. 48(10): 1370-1381 (PMID: 20202476) Abstract
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18.- Sagredo, O, González, S, Aroyo, I, Pazos, MR, Benito, C, Lastres-Becker, I , Romero, JP, Tolón, RM, Mechoulam, R, Brouillet, E, Romero, J, Fernández-Ruiz, J. (2009). Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease. Glia. 57(11): 1154-1167 (PMID: 19115380) Abstract
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19.- Innamorato, NG , Lastres-Becker, I , Cuadrado, A . (2009). Role of microglial redox balance in modulation of neuroinflammation. Curr. Opin. Neurol. 22(3): 308-314 (PMID: 19359988) Abstract
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20.- Lastres-Becker, I , Fernández-Pérez, A , Cebolla, B , Vallejo, M . (2008). Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1. Mol. Cell. Neurosci. 39(3): 291-301 (PMID: 18707003) Abstract
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21.- Lastres-Becker, I , Rüb, U, Auburger, G. (2008). Spinocerebellar ataxia 2 (SCA2). Cerebellum. 7(2): 115-124 (PMID: 18418684) Abstract
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22.- Lastres-Becker, I , Brodesser, S, Lütjohann, D, Azizov, M, Buchmann, J, Hintermann, E, Sandhoff, K, Schürmann, A, Nowock, J, Auburger, G. (2008). Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum. Mol. Genet. 17(10): 1465-1481 (PMID: 18250099) Abstract
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23.- Lastres-Becker, I , Fernández-Ruiz, J. (2006). An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments. Curr. Med. Chem. 13(30): 3705-3718 (PMID: 17168732) Abstract
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24.- Lastres-Becker, I , Cartmell, T, Molina-Holgado, F. (2006). Endotoxin preconditioning protects neurones from in vitro ischemia: role of endogenous IL-1beta and TNF-alpha. J. Neuroimmunol. 173(1-2): 108-116 (PMID: 16439029) Abstract
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25.- Lastres-Becker, I , Molina-Holgado, F, Ramos, JA, Mechoulam, R, Fernández-Ruiz, J. (2005). Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiol. Dis. 19(1-2): 96-9107 (PMID: 15837565) Abstract
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26.- González, S, Mena, MA, Lastres-Becker, I , Serrano, A, de Yébenes, JG, Ramos, JA, Fernández-Ruiz, J. (2005). Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice. Brain Res. 1046(1-2): 195-206 (PMID: 15882845) Abstract
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27.- Lastres-Becker, I , Bizat, N, Boyer, F, Hantraye, P, Fernández-Ruiz, J, Brouillet, E. (2004). Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo. Neuroreport. 15(15): 2375-2379 (PMID: 15640759) Abstract
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28.- de Lago, E, de Miguel, R, Lastres-Becker, I , Ramos, JA, Fernández-Ruiz, J. (2004). Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. Brain Res. 1007(1-2): 152-159 (PMID: 15064146) Abstract
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29.- Lastres-Becker, I , De Miguel, R, Fernández-Ruiz, JJ. (2003). The endocannabinoid system and Huntington's disease. Curr Drug Targets CNS Neurol Disord. 2(5): 335-347 (PMID: 14529364) Abstract
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30.- Lastres-Becker, I , Bizat, N, Boyer, F, Hantraye, P, Brouillet, E, Fernández-Ruiz, J. (2003). Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. Neuroreport. 14(6): 813-816 (PMID: 12858038) Abstract
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31.- Lastres-Becker, I , Gómez, M, De Miguel, R, Ramos, JA, Fernández-Ruiz, J. (2003). Loss of cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease. Neurotox Res. 4(7-8): 601-608 (PMID: 12709298) Abstract
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32.- Lastres-Becker, I , de Miguel, R, De Petrocellis, L, Makriyannis, A, Di Marzo, V, Fernández-Ruiz, J. (2003). Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J. Neurochem. 84(5): 1097-1109 (PMID: 12603833) Abstract
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33.- Fernández-Ruiz, J, Lastres-Becker, I , Cabranes, A, González, S, Ramos, JA. (2002). Endocannabinoids and basal ganglia functionality. Prostaglandins Leukot. Essent. Fatty Acids. 66(2-3): 257-267 (PMID: 12052041) Abstract
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34.- Romero, J, Lastres-Becker, I , de Miguel, R, Berrendero, F, Ramos, JA, Fernández-Ruiz, J. (2002). The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects. Pharmacol. Ther. 95(2): 137-152 (PMID: 12182961) Abstract
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35.- Lastres-Becker, I , Hansen, HH, Berrendero, F, De Miguel, R, Pérez-Rosado, A, Manzanares, J, Ramos, JA, Fernández-Ruiz, J. (2002). Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease. Synapse. 44(1): 23-35 (PMID: 11842443) Abstract
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36.- Lastres-Becker, I , Berrendero, F, Lucas, JJ, Martín-Aparicio, E, Yamamoto, A, Ramos, JA, Fernández-Ruiz, JJ. (2002). Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's disease. Brain Res. 929(2): 236-242 (PMID: 11864629) Abstract
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37.- López-Rodríguez, ML, Viso, A, Ortega-Gutiérrez, S, Lastres-Becker, I , González, S, Fernández-Ruiz, J, Ramos, JA. (2001). Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors. J. Med. Chem. 44(26): 4505-4508 (PMID: 11741470) Abstract
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38.- Lastres-Becker, I , Cebeira, M, de Ceballos, ML, Zeng, BY, Jenner, P, Ramos, JA, Fernández-Ruiz, JJ. (2001). Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets. Eur. J. Neurosci. 14(11): 1827-1832 (PMID: 11860478) Abstract
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39.- Hansen, HH, Schmid, PC, Bittigau, P, Lastres-Becker, I , Berrendero, F, Manzanares, J, Ikonomidou, C, Schmid, HH, Fernández-Ruiz, JJ, Hansen, HS. (2001). Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. J. Neurochem. 78(6): 1415-1427 (PMID: 11579150) Abstract
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40.- Lastres-Becker, I , Fezza, F, Cebeira, M, Bisogno, T, Ramos, JA, Milone, A, Fernández-Ruiz, J, Di Marzo, V. (2001). Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease. Neuroreport. 12(10): 2125-2129 (PMID: 11447320) Abstract
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41.- Di Marzo, V, Lastres-Becker, I , Bisogno, T, De Petrocellis, L, Milone, A, Davis, JB, Fernandez-Ruiz, JJ. (2001). Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. Eur. J. Pharmacol. 420(2-3): 123-131 (PMID: 11408034) Abstract
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42.- González, S, Romero, J, de Miguel, R, Lastres-Becker, I , Villanua, MA, Makriyannis, A, Ramos, JA, Fernández-Ruiz, JJ. (1999). Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. Life Sci. 65(3): 327-336 (PMID: 10447218) Abstract
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43.- Linnertz, H, Lastres Becker, I , Krumscheid, R, Amler, E, Thoenges, D, Schoner, W. (1997). 2'(3')-O-[N- [2- [3- [5-fluoresceinyl] thioureido] ethyl] carbamoyl] adenosine 5'-triphosphate and its Cr(H2O)4 and Co(NH3)4 complex derivatives are new fluorescent tools for labelling ATP binding sites of Na+/K+-ATPase. Physiol Res. 46(5): 345-349 (PMID: 9728479) Abstract
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