Publications
Articles Published in   María Jesús Obregón Perea   

1.- Sevillano, J, Sánchez-Alonso, MG, Zapatería, B, Calderón, M, Alcalá, M, Limones, M, Pita, J, Gramage, E, Vicente-Rodríguez, M, Horrillo, D, Medina-Gómez, G, Obregón, MJ , Viana, M, Valladolid-Acebes, I, Herradón, G, Ramos-Álvarez, MP. (2018). Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice. Diabetologia. (PMID: 30327824) Abstract
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2.- Bárez-López, S , Obregon, MJ , Bernal, J , Guadaño-Ferraz, A . (2018). Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development. Cereb. Cortex. 28(5): 1783-1793 (PMID: 28407057) Abstract
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3.- Lucia, FS, Pacheco-Torres, J , González-Granero, S, Canals, S, Obregón, MJ , García-Verdugo, JM, Berbel, P. (2018). Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study. Front Neuroanat. 12: 31 (PMID: 29755326) Abstract
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4.- Ridruejo, E, Romero-Caími, G, Obregón, MJ , Kleiman de Pisarev, D, Alvarez, L. (2018). Potential Molecular Targets of Statins in the Prevention of Hepatocarcinogenesis. Ann Hepatol. 17(3): 490-500 (PMID: 29735800) Abstract
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5.- Gil-Ibañez, P , Belinchon, MM , Obregon, MJ , Morte, B , Bernal, J . (2017). Is the intrinsic genomic activity of thyroxine relevant in vivo? Insight from the effects on gene expression in primary cerebrocortical and neuroblastoma cells. Thyroid. (PMID: 28605984) Abstract
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6.- García-Casarrubios, E, de Moura, C, Arroba, AI , Pescador, N , Calderon-Dominguez, M, Garcia, L, Herrero, L, Serra, D, Cadenas, S, Reis, F, Carvalho, E, Obregon, MJ , Valverde, ÁM . (2016). Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochim. Biophys. Acta. 1861(12 Pt A): 1929-1941 (PMID: 27686967) Abstract
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7.- Calderon-Dominguez, M, Sebastián, D, Fucho, R, Weber, M, Mir, JF, García-Casarrubios, E, Obregón, MJ , Zorzano, A, Valverde, ÁM , Serra, D, Herrero, L. (2016). Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes. PLoS ONE. 11(7): e0159399 (PMID: 27438137) Abstract
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8.- Martinez-deMena, R , Calvo, RM , Garcia, L, Obregon, MJ . (2016). Effect of glucocorticoids on the activity, expression and proximal promoter of type II deiodinase in rat brown adipocytes. Mol. Cell. Endocrinol. 428: 58-67 (PMID: 26994513) Abstract
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9.- Bárez-López, S , Obregon, MJ , Martínez-de-Mena, R , Bernal, J , Guadaño-Ferraz, A , Morte, B . (2016). Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution. Thyroid. 26(5): 618-626 (PMID: 26701289) Abstract
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10.- Martinez-deMena, R , Anedda, A, Cadenas, S, Obregon, MJ . (2015). TSH effects on thermogenesis in rat brown adipocytes. Mol. Cell. Endocrinol. 404: 151-158 (PMID: 25662278) Abstract
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11.- Navarro, D, Alvarado, M, Navarrete, F, Giner, M, Obregon, MJ , Manzanares, J, Berbel, P. (2015). Gestational and early postnatal hypothyroidism alters VGluT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats. Front Neuroanat. 9: 9 (PMID: 25741243) Abstract
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12.- Gabrielsen, KM, Krokstad, JS, Villanger, GD, Blair, DA, Obregon, MJ , Sonne, C, Dietz, R, Letcher, RJ, Jenssen, BM. (2015). Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus). Environ. Res. 136: 413-423 (PMID: 25460663) Abstract
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13.- Obregon, MJ . (2014). Adipose tissues and thyroid hormones. Front Physiol. 5: 479 (PMID: 25566082) Abstract
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14.- Bárez-López, S , Bosch-García, D , Gómez-Andrés, D, Pulido-Valdeolivas, I, Montero-Pedrazuela, A , Obregon, MJ , Guadaño-Ferraz, A . (2014). Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase. PLoS ONE. 9(8): e103857 (PMID: 25083788) Abstract
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15.- Núñez, B, Martínez de Mena, R, Obregon, MJ , Font-Llitjós, M, Nunes, V, Palacín, M, Dumitrescu, AM, Morte, B , Bernal, J . (2014). Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. PLoS ONE. 9(5): e96915 (PMID: 24819605) Abstract
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16.- Obregon, MJ . (2014). Changing white into brite adipocytes. Focus on "BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells". Am. J. Physiol., Cell Physiol. 306(5): C425-7 (PMID: 24429067)
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17.- Selmi-Ruby, S, Bouazza, L, Obregon, MJ , Conscience, A, Flamant, F, Samarut, J, Borson-Chazot, F, Rousset, B. (2014). The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. Endocrinology. 155(2): 635-646 (PMID: 24265449) Abstract
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18.- Bianco, AC, Anderson, G, Forrest, D, Galton, VA, Gereben, B, Kim, BW, Kopp, PA, Liao, XH, Obregon, MJ , Peeters, RP, Refetoff, S, Sharlin, DS, Simonides, WS, Weiss, RE, Williams, GR, , . (2014). American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid. 24(1): 88-8168 (PMID: 24001133) Abstract
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19.- Castro, I, Quisenberry, L, Calvo, RM , Obregon, MJ , Lado-Abeal, J. (2013). Septic shock non-thyroidal illness syndrome causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone. J. Mol. Endocrinol. 50(2): 255-266 (PMID: 23296981) Abstract
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20.- Lavado-Autric, R, Calvo, RM , de Mena, RM , de Escobar, GM , Obregon, MJ . (2013). Deiodinase activities in thyroids and tissues of iodine-deficient female rats. Endocrinology. 154(1): 529-536 (PMID: 23142811) Abstract
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21.- Garcia, B, Martinez-de-Mena, R , Obregon, MJ . (2012). Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPK. Biochim. Biophys. Acta. 1821(10): 1309-1315 (PMID: 22766489) Abstract
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22.- Tinahones, FJ, Coín-Aragüez, L, Mayas, MD, Garcia-Fuentes, E, Hurtado-Del-Pozo, C, Vendrell, J, Cardona, F, Calvo, RM , Obregon, MJ , El Bekay, R. (2012). Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels. BMC Physiol. 12: 4 (PMID: 22471305) Abstract
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23.- Hernandez, A , de Mena, RM , Martin, E, Obregon, MJ . (2011). Differences in the response of UCP1 mRNA to hormonal stimulation between rat and mouse primary cultures of brown adipocytes. Cell. Physiol. Biochem. 28(5): 969-980 (PMID: 22178948) Abstract
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24.- Hurtado del Pozo, C , Vesperinas-García, G, Rubio, MÁ, Corripio-Sánchez, R, Torres-García, AJ, Obregon, MJ , Calvo, RM . (2011). ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity. Biochim. Biophys. Acta. 1811(12): 1194-1200 (PMID: 21840420) Abstract
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25.- Negro, R, Soldin, OP, Obregon, MJ , Stagnaro-Green, A. (2011). Hypothyroxinemia and pregnancy. Endocr Pract. 17(3): 422-429 (PMID: 21247845) Abstract
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26.- Calvo, RM , Obregon, MJ . (2011). Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue. Metab. Clin. Exp. 60(9): 1207-1210 (PMID: 21397282) Abstract
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27.- del Pozo, CH , Calvo, RM , Vesperinas-García, G, Gómez-Ambrosi, J, Frühbeck, G, Rubio, MA, Obregon, MJ . (2011). Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes. Obes Surg. 21(5): 633-643 (PMID: 20686928) Abstract
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28.- Martinez de Mena, R , Scanlan, TS, Obregon, MJ . (2010). The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology. 151(10): 5074-5083 (PMID: 20719854) Abstract
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29.- Obregon, MJ . (2010). Maternal obesity results in offspring prone to metabolic syndrome. Endocrinology. 151(8): 3475-3476 (PMID: 20660073)
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30.- Hurtado del Pozo, C , Calvo, RM , Vesperinas-García, G, Gómez-Ambrosi, J, Frühbeck, G, Corripio-Sánchez, R, Rubio, MA, Obregon, MJ . (2010). IPO8 and FBXL10: new reference genes for gene expression studies in human adipose tissue. Obesity (Silver Spring). 18(5): 897-903 (PMID: 19876011) Abstract
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31.- Lado-Abeal, J, Calvo, RM , Victoria, B, Castro, I, Obregon, MJ , Araujo-Vilar, D. (2010). Regional decrease of subcutaneous adipose tissue in patients with type 2 familial partial lipodystrophy is associated with changes in thyroid hormone metabolism. Thyroid. 20(4): 419-424 (PMID: 20373986) Abstract
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32.- Calvo, RM , Obregon, MJ . (2009). Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes. Mol. Cell. Endocrinol. 311(1-2): 39-46 (PMID: 19619606) Abstract
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33.- Isorna, E, Obregon, MJ , Calvo, RM , Vázquez, R, Pendón, C, Falcón, J, Muñoz-Cueto, JA. (2009). Iodothyronine deiodinases and thyroid hormone receptors regulation during flatfish (Solea senegalensis) metamorphosis. J. Exp. Zool. B Mol. Dev. Evol. 312B(3): 231-246 (PMID: 19306324) Abstract
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34.- de Escobar, GM , Ares, S , Berbel, P, Obregón, MJ , del Rey, FE . (2008). The changing role of maternal thyroid hormone in fetal brain development. Semin. Perinatol. 32(6): 380-386 (PMID: 19007674) Abstract
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35.- Medina-Gomez, G , Calvo, RM , Obregon, MJ . (2008). Thermogenic effect of triiodothyroacetic acid at low doses in rat adipose tissue without adverse side effects in the thyroid axis. Am. J. Physiol. Endocrinol. Metab. 294(4): E688-97 (PMID: 18285526) Abstract
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36.- Simonides, WS, Mulcahey, MA, Redout, EM, Muller, A, Zuidwijk, MJ, Visser, TJ, Wassen, FW, Crescenzi, A, da-Silva, WS, Harney, J, Engel, FB, Obregon, MJ , Larsen, PR, Bianco, AC, Huang, SA. (2008). Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J. Clin. Invest. 118(3): 975-983 (PMID: 18259611) Abstract
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37.- Obregon, MJ . (2008). Thyroid hormone and adipocyte differentiation. Thyroid. 18(2): 185-195 (PMID: 18279019) Abstract
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38.- Palos, F, García-Rendueles, ME, Araujo-Vilar, D, Obregon, MJ , Calvo, RM , Cameselle-Teijeiro, J, Bravo, SB, Perez-Guerra, O, Loidi, L, Czarnocka, B, Alvarez, P, Refetoff, S, Dominguez-Gerpe, L, Alvarez, CV, Lado-Abeal, J. (2008). Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies. J. Clin. Endocrinol. Metab. 93(1): 267-277 (PMID: 17940114) Abstract
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39.- de Escobar, GM , Obregón, MJ , del Rey, FE . (2007). Iodine deficiency and brain development in the first half of pregnancy. Public Health Nutr. 10(12A): 1554-1570 (PMID: 18053280) Abstract
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40.- Berbel, P, Obregón, MJ , Bernal, J , Escobar del Rey, F , Morreale de Escobar, G . (2007). Iodine supplementation during pregnancy: a public health challenge. Trends Endocrinol. Metab. 18(9): 338-343 (PMID: 17962037) Abstract
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41.- Obregon, MJ , Calvo, RM , Del Rey, FE, de Escobar, GM . (2007). Ontogenesis of thyroid function and interactions with maternal function. Endocr Dev. 10: 86-98 (PMID: 17684391) Abstract
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42.- Hernandez, A , Garcia, B, Obregon, MJ . (2007). Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes. Endocrinology. 148(8): 3968-3976 (PMID: 17510246) Abstract
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43.- Pedraza, PE , Obregon, MJ , Escobar-Morreale, HF , del Rey, FE , de Escobar, GM . (2006). Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man. Endocrinology. 147(5): 2098-2108 (PMID: 16455775) Abstract
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44.- Barrantes, Idel B, Montero-Pedrazuela, A , Guadaño-Ferraz, A , Obregon, MJ , Martinez de Mena, R , Gailus-Durner, V, Fuchs, H, Franz, TJ, Kalaydjiev, S, Klempt, M, Hölter, S, Rathkolb, B, Reinhard, C, Morreale de Escobar, G , Bernal, J , Busch, DH, Wurst, W, Wolf, E, Schulz, H, Shtrom, S, Greiner, E, Hrabé de Angelis, M, Westphal, H, Niehrs, C. (2006). Generation and characterization of dickkopf3 mutant mice. Mol. Cell. Biol. 26(6): 2317-2326 (PMID: 16508007) Abstract
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45.- Obregon, MJ , Escobar del Rey, F , Morreale de Escobar, G . (2005). The effects of iodine deficiency on thyroid hormone deiodination. Thyroid. 15(8): 917-929 (PMID: 16131334) Abstract
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46.- Alvarez, L , Hernández, S, Martinez-de-Mena, R , Kolliker-Frers, R, Obregón, MJ , Kleiman de Pisarev, DL. (2005). The role of type I and type II 5' deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status. Toxicology. 207(3): 349-362 (PMID: 15664263) Abstract
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47.- Martinez-deMena, R , Obregón, MJ . (2005). Insulin increases the adrenergic stimulation of 5' deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K. J. Mol. Endocrinol. 34(1): 139-151 (PMID: 15691884) Abstract
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48.- Morreale de Escobar, G , Obregon, MJ , Escobar del Rey, F . (2004). Role of thyroid hormone during early brain development. Eur. J. Endocrinol. 151 Suppl 3: U25-37 (PMID: 15554884) Abstract
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49.- Kester, MH, Martinez de Mena, R , Obregon, MJ , Marinkovic, D, Howatson, A, Visser, TJ, Hume, R, Morreale de Escobar, G . (2004). Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. J. Clin. Endocrinol. Metab. 89(7): 3117-3128 (PMID: 15240580) Abstract
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50.- de Escobar, GM , Obregón, MJ , del Rey, FE . (2004). Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract. Res. Clin. Endocrinol. Metab. 18(2): 225-248 (PMID: 15157838) Abstract
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51.- Medina-Gomez, G , Calvo, RM , Obregón, MJ . (2004). T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes. Biochim. Biophys. Acta. 1682(1-3): 38-47 (PMID: 15158754) Abstract
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52.- Pascual-Leone, AM, Ramos, S, Goya, L, Alvarez, C, Escrivá, F, Obregón, MJ . (2003). Age-dependent adaptation of the liver thyroid status and recovery of serum levels and hepatic insulin-like growth factor-I expression in neonatal and adult diabetic rats. Metab. Clin. Exp. 52(9): 1117-1125 (PMID: 14506616) Abstract
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53.- Medina-Gomez, G , Hernàndez, A, Calvo, RM , Martin, E, Obregón, MJ . (2003). Potent thermogenic action of triiodothyroacetic acid in brown adipocytes. Cell. Mol. Life Sci. 60(9): 1957-1967 (PMID: 14523556) Abstract
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54.- Carmona, MC, Iglesias, R, Obregón, MJ , Darlington, GJ, Villarroya, F, Giralt, M. (2002). Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277(24): 21489-21498 (PMID: 11940593) Abstract
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55.- Martinez-deMena, R , Hernández, A, Obregón, MJ . (2002). Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 282(5): E1119-27 (PMID: 11934678) Abstract
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56.- García, B , Obregón, MJ . (2002). Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes. Am. J. Physiol., Cell Physiol. 282(1): C105-12 (PMID: 11742803) Abstract
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57.- Schröder-van der Elst, JP, van der Heide, D, Kastelijn, J, Rousset, B, Obregón, MJ . (2001). The expression of the sodium/iodide symporter is up-regulated in the thyroid of fetuses of iodine-deficient rats. Endocrinology. 142(9): 3736-3741 (PMID: 11517148) Abstract
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58.- Aláez, C, Calvo, R , Obregón, MJ , Alvarez, C, Goya, L, Escrivá, F, Martín, MA, Pascual-Leone, AM. (2001). Influence of type II 5' deiodinase on TSH content in diabetic rats. J. Physiol. Biochem. 57(3): 221-230 (PMID: 11800284) Abstract
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59.- Morreale de Escobar, G , Obregón, MJ , Escobar del Rey, F . (2000). Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?. J. Clin. Endocrinol. Metab. 85(11): 3975-3987 (PMID: 11095417) Abstract
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60.- Hernández, A, Obregón, MJ . (2000). Triiodothyronine amplifies the adrenergic stimulation of uncoupling protein expression in rat brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 278(5): E769-77 (PMID: 10780931) Abstract
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61.- Barroso, I , Benito, B, Garcí-Jiménez, C, Hernández, A, Obregón, MJ , Santisteban, P . (1999). Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation. Eur. J. Endocrinol. 141(2): 169-179 (PMID: 10427161) Abstract
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62.- Escobar-Morreale, HF , Obregón, MJ , Escobar del Rey, F , Morreale de Escobar, G . (1999). Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms?. Biochimie. 81(5): 453-462 (PMID: 10403175) Abstract
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63.- Calvo, RM , Roda, JM, Obregón, MJ , Morreale de Escobar, G . (1998). Thyroid hormones in human tumoral and normal nervous tissues. Brain Res. 801(1-2): 150-157 (PMID: 9729351) Abstract
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64.- Calvo, RM , Forcen, R, Obregon, MJ , Escobar del Rey, F , Morreale de Escobar, G , Regadera, J. (1998). Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration. Anat. Rec. 251(2): 173-180 (PMID: 9624446) Abstract
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65.- Schröder-van der Elst, JP, van der Heide, D, Morreale de Escobar, G , Obregón, MJ . (1998). Iodothyronine deiodinase activities in fetal rat tissues at several levels of iodine deficiency: a role for the skin in 3,5,3'-triiodothyronine economy?. Endocrinology. 139(5): 2229-2234 (PMID: 9564827) Abstract
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66.- Hernández, A, St Germain, DL, Obregón, MJ . (1998). Transcriptional activation of type III inner ring deiodinase by growth factors in cultured rat brown adipocytes. Endocrinology. 139(2): 634-639 (PMID: 9449635) Abstract
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67.- García, B , Obregón, MJ . (1997). Norepinephrine potentiates the mitogenic effect of growth factors in quiescent brown preadipocytes: relationship with uncoupling protein messenger ribonucleic acid expression. Endocrinology. 138(10): 4227-4233 (PMID: 9322934) Abstract
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68.- Guadaño-Ferraz, A , Obregón, MJ , St Germain, DL, Bernal, J . (1997). The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proc. Natl. Acad. Sci. U.S.A. 94(19): 10391-10396 (PMID: 9294221) Abstract
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69.- Escobar-Morreale, HF , Obregón, MJ , Hernandez, A, Escobar del Rey, F , Morreale de Escobar, G . (1997). Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine. Endocrinology. 138(6): 2559-2568 (PMID: 9165049) Abstract
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70.- Calvo, R , Morreale de Escobar, G , Escobar del Rey, F , Obregón, MJ . (1997). Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model. Endocrinology. 138(3): 1159-1169 (PMID: 9048623) Abstract
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71.- Calvo, R , Morreale de Escobar, G , Escobar del Rey, F , Obregón, MJ . (1997). Maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status. Thyroid. 7(1): 79-87 (PMID: 9086576) Abstract
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72.- Pedraza, P , Calvo, R , Obregón, MJ , Asunción, M , Escobar del Rey, F , Morreale de Escobar, GM . (1996). Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses. Endocrinology. 137(11): 4902-4914 (PMID: 8895363) Abstract
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73.- Obregón, MJ , Calvo, R , Hernández, A, Escobar del Rey, F , Morreale de Escobar, G . (1996). Regulation of uncoupling protein messenger ribonucleic acid and 5'-deiodinase activity by thyroid hormones in fetal brown adipose tissue. Endocrinology. 137(11): 4721-4729 (PMID: 8895339) Abstract
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74.- Hernández, A, Obregón, MJ . (1996). Presence and mRNA expression of T3 receptors in differentiating rat brown adipocytes. Mol. Cell. Endocrinol. 121(1): 37-46 (PMID: 8865164) Abstract
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75.- Hernández, A, Obregón, MJ . (1996). T3 potentiates the adrenergic stimulation of type II 5'-deiodinase activity in cultured rat brown adipocytes. Am. J. Physiol. 271(1 Pt 1): E15-23 (PMID: 8760076) Abstract
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76.- Escobar-Morreale, HF , del Rey, FE, Obregón, MJ , de Escobar, GM . (1996). Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology. 137(6): 2490-2502 (PMID: 8641203) Abstract
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77.- Solé, E, Calvo, R , Obregón, MJ , Meseguer, A. (1996). Effects of thyroid hormone on the androgenic expression of KAP gene in mouse kidney. Mol. Cell. Endocrinol. 119(2): 147-159 (PMID: 8807634) Abstract
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78.- Obregón, MJ , Cannon, B, Nedergaard, J. (1996). Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum. Biochem. J. 314 ( Pt 1): 261-267 (PMID: 8660292) Abstract
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79.- Escobar-Morreale, HF , Obregón, MJ , Escobar del Rey, F , Morreale de Escobar, G . (1995). Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J. Clin. Invest. 96(6): 2828-2838 (PMID: 8675653) Abstract
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80.- Hernández, A, Obregón, MJ . (1995). Presence of growth factors-induced type III iodothyronine 5-deiodinase in cultured rat brown adipocytes. Endocrinology. 136(10): 4543-4550 (PMID: 7664675) Abstract
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81.- Pascual-Leone, AM, Aláez, C, Calvo, R , Martín, MA, Obregón, MJ . (1994). Effects of thyroid hormone deiodination on regulation of thyroid axis in undernourished rats. Am. J. Physiol. 267(6 Pt 1): E983-9 (PMID: 7810644) Abstract
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82.- Solé, E, Calvo, R , Obregón, MJ , Meseguer, A. (1994). Thyroid hormone controls the cell-specific expression of the kidney androgen-regulated protein gene in S3 mouse kidney cells. Endocrinology. 135(5): 2120-2129 (PMID: 7956935) Abstract
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83.- Morreale de Escobar, G , Calvo, R , Escobar del Rey, F , Obregón, MJ . (1994). Thyroid hormones in tissues from fetal and adult rats. Endocrinology. 134(6): 2410-2415 (PMID: 8194467) Abstract
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84.- Perez-Castillo, A , Hernandez, A, Pipaon, C, Santos, A , Obregon, MJ . (1993). Multiple regulation of S14 gene expression during brown fat differentiation. Endocrinology. 133(2): 545-552 (PMID: 8393767) Abstract
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85.- Hernandez, A, Garcia-Jimenez, C , Santisteban, P , Obregon, MJ . (1993). Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes. Eur. J. Biochem. 215(2): 285-290 (PMID: 8393790) Abstract
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86.- Morreale de Escobar, G , Calvo, R , Escobar del Rey, F , Obregon, MJ . (1993). Differential effects of thyroid hormones on growth and thyrotropic hormones in rat fetuses near term. Endocrinology. 132(5): 2056-2064 (PMID: 8477656) Abstract
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87.- García-Jimenez, C , Hernández, A, Obregón, MJ , Santisteban, P . (1993). Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine. Endocrinology. 132(4): 1537-1543 (PMID: 8462451) Abstract
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88.- Morreale de Escobar, G , Obregón, MJ , Calvo, R , Escobar del Rey, F . (1993). Effects of iodine deficiency on thyroid hormone metabolism and the brain in fetal rats: the role of the maternal transfer of thyroxin. Am. J. Clin. Nutr. 57(2 Suppl): 280S-285S (PMID: 8427205) Abstract
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89.- Morreale de Escobar, G , Calvo, R , Obregon, MJ , Escobar del Rey, F . (1992). Homeostasis of brain T3 in rat fetuses and their mothers: effects of thyroid status and iodine deficiency. Acta Med. Austriaca. 19 Suppl 1: 110-116 (PMID: 1519443) Abstract
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90.- Calvo, R , Obregón, MJ , Escobar del Rey, F , Morreale de Escobar, G . (1992). The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status. Endocrinology. 131(1): 357-365 (PMID: 1612015) Abstract
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91.- Aláez, C, Calvo, R , Obregón, MJ , Pascual-Leone, AM. (1992). Thyroid hormones and 5'-deiodinase activity in neonatal undernourished rats. Endocrinology. 130(2): 773-779 (PMID: 1733724) Abstract
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92.- Obregón, MJ , Ruiz de Oña, C, Calvo, R , Escobar del Rey, F , Morreale de Escobar, G . (1991). Outer ring iodothyronine deiodinases and thyroid hormone economy: responses to iodine deficiency in the rat fetus and neonate. Endocrinology. 129(5): 2663-2673 (PMID: 1935795) Abstract
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93.- Gil-Garay, R, Miralles-Flores, C, Obregón, MJ , Escobar del Rey, F , Morreale de Escobar, G , Delgado-Baeza, E. (1991). Maternal hypothyroidism and fetal chondro-osseous development in rats. Biol. Neonate. 60(6): 385-394 (PMID: 1797134) Abstract
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94.- Morreale de Escobar, G , Obregón, MJ , Calvo, R , Escobar del Rey, F . (1991). Maternal thyroid hormones during pregnancy: effects on the fetus in congenital hypothyroidism and in iodine deficiency. Adv. Exp. Med. Biol. 299: 133-156 (PMID: 1810132)
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95.- Ruiz de Oña, C, Morreale de Escobar, G , Calvo, R , Escobar del Rey, F , Obregón, MJ . (1991). Thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism. Endocrinology. 128(1): 422-432 (PMID: 1986934) Abstract
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96.- Calvo, R , Obregón, MJ , Ruiz de Oña, C, Escobar del Rey, F , Morreale de Escobar, G . (1990). Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain. J. Clin. Invest. 86(3): 889-899 (PMID: 2394838) Abstract
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97.- Calvo, R , Obregon, MJ , Ruiz de Oña, C, Ferreiro, B, Escobar Del Rey, E , Morreale de Escobar, G . (1990). Thyroid hormone economy in pregnant rats near term: a "physiological" animal model of nonthyroidal illness?. Endocrinology. 127(1): 10-16 (PMID: 2113860) Abstract
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98.- Morreale de Escobar, G , Calvo, R , Obregon, MJ , Escobar Del Rey, F . (1990). Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term. Endocrinology. 126(5): 2765-2767 (PMID: 2328706) Abstract
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99.- Obregón, MJ , Ruiz de Oña, C, Hernandez, A, Calvo, R , Escobar del Rey, F , Morreale de Escobar, G . (1989). Thyroid hormones and 5'-deiodinase in rat brown adipose tissue during fetal life. Am. J. Physiol. 257(5 Pt 1): E625-31 (PMID: 2688435) Abstract
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100.- Rehnmark, S, Kopecký, J, Jacobsson, A, Néchad, M, Herron, D, Nelson, BD, Obregon, MJ , Nedergaard, J, Cannon, B. (1989). Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine. Exp. Cell Res. 182(1): 75-83 (PMID: 2497023) Abstract
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101.- Obregón, MJ , Jacobsson, A, Kirchgessner, T, Schotz, MC, Cannon, B, Nedergaard, J. (1989). Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase. Biochem. J. 259(2): 341-346 (PMID: 2497735) Abstract
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102.- Escobar del Rey, F , Ruiz de Oña, C, Bernal, J , Obregón, MJ , Morreale de Escobar, G . (1989). Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels. Acta Endocrinol. 120(4): 490-498 (PMID: 2718701) Abstract
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103.- Morreale de Escobar, G , Obregón, MJ , Ruiz de Oña, C, Escobar del Rey, F . (1989). Comparison of maternal to fetal transfer of 3,5,3'-triiodothyronine versus thyroxine in rats, as assessed from 3,5,3'-triiodothyronine levels in fetal tissues. Acta Endocrinol. 120(1): 20-30 (PMID: 2911938) Abstract
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104.- Morreale de Escobar, G , Obregon, MJ , Escobar del Rey, F . (1988). Maternal-fetal thyroid hormone relationships and the fetal brain. Acta Med. Austriaca. 15 Suppl 1: 66-70 (PMID: 3176827) Abstract
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105.- Ruiz de Oña, C, Obregón, MJ , Escobar del Rey, F , Morreale de Escobar, G . (1988). Developmental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones. Pediatr. Res. 24(5): 588-594 (PMID: 3205610) Abstract
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106.- Viñas, O, Giralt, M, Obregón, MJ , Iglesias, R, Villarroya, F, Mampel, T. (1988). Iodothyronine 5'-deiodinase activity and thyroid hormone content in brown adipose tissue during the breeding cycle of the rat. Biochem. J. 255(2): 457-461 (PMID: 3060112) Abstract
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107.- Morreale de Escobar, G , Obregon, MJ , Ruiz de Oña, C, Escobar del Rey, F . (1988). Transfer of thyroxine from the mother to the rat fetus near term: effects on brain 3,5,3'-triiodothyronine deficiency. Endocrinology. 122(4): 1521-1531 (PMID: 3345725) Abstract
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108.- Obregon, MJ , Pitamber, R, Jacobsson, A, Nedergaard, J, Cannon, B. (1987). Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups. Biochem. Biophys. Res. Commun. 148(1): 9-14 (PMID: 3118877) Abstract
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109.- Morreale de Escobar, G , Obregon, MJ , Escobar del Rey, F . (1987). Fetal and maternal thyroid hormones. Horm. Res. 26(1-4): 12-27 (PMID: 3297961) Abstract
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110.- Obregon, MJ , Mills, I, Silva, JE, Larsen, PR. (1987). Catecholamine stimulation of iodothyronine 5'-deiodinase activity in rat dispersed brown adipocytes. Endocrinology. 120(3): 1069-1072 (PMID: 3803310) Abstract
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111.- Iglesias, R, Fernandez, JA, Mampel, T, Obregón, MJ , Villarroya, F. (1987). Iodothyronine 5'-deiodinase activity in rat brown adipose tissue during development. Biochim. Biophys. Acta. 923(2): 233-240 (PMID: 3814615) Abstract
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112.- Obregon, MJ , Larsen, PR, Silva, JE. (1986). The role of 3,3',5'-triiodothyronine in the regulation of type II iodothyronine 5'-deiodinase in the rat cerebral cortex. Endocrinology. 119(5): 2186-2192 (PMID: 3769868) Abstract
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113.- Morreale de Escobar, G , Pastor, R, Obregon, MJ , Escobar del Rey, F . (1985). Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology. 117(5): 1890-1900 (PMID: 4042969) Abstract
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114.- Obregon, MJ , Larsen, PR, Silva, JE. (1985). Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat. Endocrinology. 116(6): 2192-2200 (PMID: 3996308) Abstract
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115.- Obregón, MJ , Santisteban, P , Rodríguez-Peña, A , Pascual, A , Cartagena, P, Ruiz-Marcos, A, Lamas, L, Escobar del Rey, F , Morreale de Escobar, G . (1984). Cerebral hypothyroidism in rats with adult-onset iodine deficiency. Endocrinology. 115(2): 614-624 (PMID: 6745172) Abstract
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116.- Ortiz-Caro, J , Obregón, MJ , Pascual, A , Jolin, T. (1984). Decreased T4 to T3 conversion in tissues of streptozotocin-diabetic rats. Acta Endocrinol. 106(1): 86-91 (PMID: 6328820) Abstract
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117.- Obregon, MJ , Mallol, J, Pastor, R, Morreale de Escobar, G , Escobar del Rey, F . (1984). L-thyroxine and 3,5,3'-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function. Endocrinology. 114(1): 305-307 (PMID: 6690276) Abstract
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118.- Mallol, J, Obregón, MJ , Morreale de Escobar, G . (1982). Analytical artifacts in radioimmunoassay of L-thyroxin in human milk. Clin. Chem. 28(6): 1277-1282 (PMID: 7074933) Abstract
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119.- Ruiz-Marcos, A, Sanchez-Toscano, F, Obregon, MJ , Escobar del Rey, F , Morreale de Escobar, G . (1982). Thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage. Brain Res. 239(2): 559-574 (PMID: 7093702) Abstract
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120.- Santisteban, P , Obregon, MJ , Rodriguez-Peña, A , Lamas, L, Del Rey, FE, De Escobar, GM. (1982). Are iodine-deficient rats euthyroid?. Endocrinology. 110(5): 1780-1789 (PMID: 6804212) Abstract
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121.- Lamas, L, Couvreur, M, Obregon, MJ , van den Hove-Vandenbroucke, MF. (1982). Effect of chronic iodide supplements on thyroid secretion: the role of lysosomes. Endocrinology. 110(5): 1804-1811 (PMID: 7075539)
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122.- van den Hove-Vandenbroucke, MF, Santisteban, P , Couvreur, M, Obregon, MJ , Lamas, L. (1982). Involution of rat iodoprive hyperplastic goiter: effect of iodide administration on thyroid function and lysosomal properties. Endocrinology. 110(5): 1812-1818 (PMID: 6176441)
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123.- Obregón, MJ . (1982). Thyroxine radioimmunoassay for population surveys using dried blood: modifications of a highly sensitive method. Ann. Clin. Biochem. 19(Pt 1): 29-34 (PMID: 7065631) Abstract
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124.- Obregon, MJ , Mallol, J, Escobar del Rey, F , Morreale de Escobar, G . (1981). Presence of L-thyroxine and 3,5,3'-triiodo-L-thyronine in tissues from thyroidectomized rats. Endocrinology. 109(3): 908-913 (PMID: 7262025) Abstract
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125.- Padron, F, Duran-Garcia, S, Obregon, MJ , Morreale de Escobar, G , Escobar del Rey, F . (1981). Specific uptake of human growth hormone by the liver of severely hypothyroid rats. J. Endocrinol. Invest. 4(1): 119-123 (PMID: 6263964) Abstract
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126.- Durán-García, S, Obregón, MJ , Morreale de Escobar, G , Escobar del Rey, F . (1981). Differential effects of hypothyroidism on the specific uptake of growth hormone and prolactin by the rat liver. Endocrinology. 108(6): 2054-2059 (PMID: 7227295) Abstract
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127.- Escobar del Rey, F , Gomez-Pan, A, Obregon, MJ , Mallol, J, Arnao, MD, Aranda, A , Morreale de Escobar, G . (1981). A survey of schoolchildren from a severe endemic goitre area in Spain. Q. J. Med. 50(198): 233-246 (PMID: 7302120) Abstract
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128.- Obregon, MJ , Kurtz, A, Ekins, R, Morreale de Escobar, G . (1981). Evaluation of free and total L-thyroxine in serum by a commercial procedure. Clin. Chem. 27(1): 149-152 (PMID: 7449098) Abstract
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129.- Obregon, MJ , Pascual, A , Mallol, J, Morreale de Escobar, G , Escobar del Rey, F . (1980). Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque). Endocrinology. 106(6): 1827-1836 (PMID: 7371594) Abstract
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130.- Duran-Garcia, S, Gomez-Nieto, J, Fouchereau-Peron, M, Padron, VF, Obregon, MJ , Morreale de Escobar, G , Escobar del Rey, F . (1979). Effects of thyroid hormones on liver binding sites for human growth hormone, as studied in the rat. Clin. Endocrinol. (Oxf). 11(3): 275-290 (PMID: 228880) Abstract
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131.- Pascual, A , Obregon, MJ , de Escobar, GM . (1979). Tyrosine hydroxylase and the conversion of L-thyroxine into 3',3,5-triiodo-L-thyronone in the rat. Endocrinology. 104(6): 1574-1579 (PMID: 36273) Abstract
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132.- Obregon, MJ , Pascual, A , de Escobar, GM , Escobar del Rey, F . (1979). Pituitary and plasma thyrotropin, thyroxine, and triiodothyronine after hyperthyroidism. Endocrinology. 104(5): 1467-1473 (PMID: 108095)
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133.- Obregon, MJ , Roelfsema, F, Morreale de Escobar, G , Escobar del Rey, F , Querido, A. (1979). Exchange of triiodothyronine derived from thyroxine with circulating triiodothyronine as studied in the rat. Clin. Endocrinol. (Oxf). 10(3): 305-315 (PMID: 455743) Abstract
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134.- Obregon, MJ , Morreale de Escobar, G , Escobar del Rey, F . (1978). Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique. Endocrinology. 103(6): 2145-2153 (PMID: 748038) Abstract
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135.- Bernal, J , Obregón, MJ . (1974). Thyroglobulin-like antigens in a goiter with impaired thyroglobulin biosynthesis. J. Clin. Endocrinol. Metab. 39(3): 592-595 (PMID: 4416644)
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