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The goals of our laboratory are 1) to identify and study new genes involved in tumor development and progression, 2) to generate new mouse models of human diseases with preclinical interest, and 3) to translate this knowledge into clinical therapies by identifying and testing new chemotherapeutic drugs and immuno-modulatory agents in patient tumor cells and preclinical mouse models. Key words: New therapies, chronic lymphocytic leukemia, CLL, lymphoma, cancer, inflammation, autoimmunity, type 2 diabetes, transgenic mice, knock-out mice, TNF-R associated factors, TRAF, TRIM37.